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生物医学应用中非热等离子体处理的技术现状:它能否帮助对抗像 COVID-19 这样的病毒性大流行?

State of the art in nonthermal plasma processing for biomedical applications: Can it help fight viral pandemics like COVID-19?

作者信息

Misra Nilanjal, Bhatt Sudhir, Arefi-Khonsari Farzaneh, Kumar Virendra

机构信息

Radiation Technology Development Division Bhabha Atomic Research Centre Trombay Mumbai Maharashtra India.

Department of Engineering and Physical Sciences Institute of Advanced Research Gandhinagar Gujarat India.

出版信息

Plasma Process Polym. 2021 Jul;18(7):2000215. doi: 10.1002/ppap.202000215. Epub 2021 May 13.

Abstract

Plasma processing finds widespread biomedical applications, such as the design of biosensors, antibiofouling surfaces, controlled drug delivery systems, and in plasma sterilizers. In the present coronavirus disease (COVID-19) situation, the prospect of applying plasma processes like surface activation, plasma grafting, plasma-enhanced chemical vapor deposition/plasma polymerization, surface etching, plasma immersion ion implantation, crosslinking, and plasma decontamination to provide timely solutions in the form of better antiviral alternatives, practical diagnostic tools, and reusable personal protective equipment is worth exploring. Herein, the role of nonthermal plasmas and their contributions toward healthcare are timely reviewed to engage different communities in assisting healthcare associates and clinicians, not only to combat the current COVID-19 pandemic but also to prevent similar kinds of future outbreaks.

摘要

等离子体处理在生物医学领域有广泛应用,如生物传感器设计、抗生物污染表面、可控药物递送系统以及等离子体灭菌器。在当前冠状病毒病(COVID-19)形势下,应用诸如表面活化、等离子体接枝、等离子体增强化学气相沉积/等离子体聚合、表面蚀刻、等离子体浸没离子注入、交联和等离子体去污等等离子体工艺,以提供更好的抗病毒替代品、实用诊断工具和可重复使用的个人防护装备等形式的及时解决方案,这一前景值得探索。在此,对非热等离子体的作用及其对医疗保健的贡献进行及时综述,以促使不同群体协助医疗保健人员和临床医生,不仅是为了抗击当前的COVID-19大流行,也是为了预防未来类似的疫情爆发。

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