Orme I M
Department of Microbiology, Colorado State University, Fort Collins 80523.
Tubercle. 1987 Dec;68(4):277-83. doi: 10.1016/0041-3879(87)90068-7.
The purpose of these experiments was to re-evaluate the usefulness of the thymectomized, irradiated, bone marrow reconstituted mouse (TXB mouse) as a model of the effect of immunodeficiency on resistance to mycobacterial infection. It was found that, although TXB mice had no resistance to intravenous infection with Mycobacterium tuberculosis, such mice were able to express moderate resistance to infection with the BCG vaccine, even when given in high doses. It is concluded, therefore, that rather than representing an animal devoid of immunological reactivity, the TXB mouse retains a residual capacity, albeit minimal, to express acquired immunity.
这些实验的目的是重新评估经胸腺切除、照射并骨髓重建的小鼠（TXB小鼠）作为免疫缺陷对抵抗分枝杆菌感染影响的模型的实用性。结果发现，尽管TXB小鼠对结核分枝杆菌的静脉感染没有抵抗力，但即使给予高剂量的卡介苗疫苗，这类小鼠仍能表现出对其感染的中度抵抗力。因此得出结论，TXB小鼠并非是缺乏免疫反应性的动物，而是保留了表达获得性免疫的残余能力，尽管这种能力很微弱。
