Division of Plastic Surgery, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
J Wound Care. 2020 Dec 1;29(Sup12):S33-S37. doi: 10.12968/jowc.2020.29.Sup12.S33.
Controlling infection and promoting healing should be the aims of hard-to-heal diabetic ulcer treatment, along with improving a patient's general condition and their blood sugar control. Many hard-to-heal diabetic ulcers present with cavities, tracks or a combination of these. There is a new biocellulose (with a nanosilver dressing) which has the ability to contour around and conform to the irregular surface of a wound bed. The purpose of this study was to evaluate its efficacy compared with a silver sulfadiazine cream, for hard-to-heal diabetic ulcer treatment.
In this randomised control trial, patients with hard-to-heal diabetic ulcers were divided into two equal-sized groups: treatment with the biocellulose with blue nanosilver (experimental group), and treatment with silver sulfadiazine cream group (control group). Cotton gauze was used as the secondary dressing for both groups. Demographic data, wound size, wound classification, wound photography and bacterial cultures were recorded at the beginning of the study. Wounds were debrided as necessary. Dressings were changed twice daily in the control group, and every three days in the experimental group.
A total of 20 patients took part in the study (10 patients in each group). The highest mean wound healing rates were 91.4% in the experimental group and 83.9% in the control group. No wound infections or adverse effects from the dressings were detected in either group.
In this study, biocellulose with blue nanosilver adapted well to the wound bed. Wound reduction was greater in the experimental group than the control group. Biocellulose with blue nanosilver could therefore be a good choice for hard-to-heal diabetic ulcer treatment, due to its good healing rates and minimal care requirements.
控制感染和促进愈合应该是治疗难以愈合的糖尿病溃疡的目标，同时改善患者的一般状况和血糖控制。许多难以愈合的糖尿病溃疡存在腔隙、轨道或两者的组合。有一种新型生物纤维素（带有纳米银敷料），它能够适应和顺应伤口床的不规则表面。本研究旨在评估其与磺胺嘧啶银乳膏治疗难以愈合的糖尿病溃疡的疗效。
在这项随机对照试验中，将难以愈合的糖尿病溃疡患者分为两组，每组各有 10 名患者：用生物纤维素蓝色纳米银治疗（实验组）和用磺胺嘧啶银乳膏治疗（对照组）。两组均使用棉纱布作为二级敷料。在研究开始时记录人口统计学数据、伤口大小、伤口分类、伤口摄影和细菌培养。必要时进行清创。对照组每天更换两次敷料，实验组每三天更换一次敷料。
共有 20 名患者参加了这项研究（每组 10 名）。实验组的最高平均伤口愈合率为 91.4%，对照组为 83.9%。两组均未发现伤口感染或敷料不良反应。
在这项研究中，蓝色纳米银生物纤维素很好地适应了伤口床。实验组的伤口缩小程度大于对照组。因此，由于良好的愈合率和最小的护理需求，蓝色纳米银生物纤维素可能是治疗难以愈合的糖尿病溃疡的一个不错的选择。
