Widdicombe J H
Cardiovascular Research Institute, University of California-San Francisco 94143.
Biorheology. 1987;24(6):551-5. doi: 10.3233/bir-1987-24605.
Airway epithelia possess transepithelial ion transport processes which may help to regulate the fluid content of airway secretions. Chloride secretion promotes fluid movement from blood to airway lumen. Active absorption of Na favours fluid movement in the opposite direction. The balance between these two processes can be altered by a number of agents which stimulate Cl secretion. The importance of ion transport for normal mucociliary clearance is suggested by the finding that airway epithelia in patients with cystic fibrosis are unable to secrete chloride. This defect may cause the characteristically sticky and tenacious mucous secretions which are the major cause of death in this disease.
气道上皮具有跨上皮离子转运过程，这可能有助于调节气道分泌物的液体含量。氯离子分泌促进液体从血液向气道管腔移动。钠离子的主动吸收有利于液体向相反方向移动。这两个过程之间的平衡可被多种刺激氯离子分泌的物质改变。囊性纤维化患者的气道上皮无法分泌氯离子这一发现表明离子转运对正常黏液纤毛清除功能很重要。这种缺陷可能导致特征性的黏稠和坚韧的黏液分泌，这是该疾病死亡的主要原因。
