Food Safety Division, Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, Telangana, India.
Symbiosis Institute of Health Sciences (SIHS), Symbiosis International (Deemed) University, Pune, Maharashtra, India.
Arch Environ Occup Health. 2022;77(2):109-124. doi: 10.1080/19338244.2020.1854646. Epub 2020 Dec 15.
Nutritional status plays a major role in determining the possible adverse health outcomes due to pesticide toxicity. The objective of the present study was to assess the organophosphorus pesticide residue levels among farm women (FW) (24-45years) and farm children (FC) (9-12 and 13-15years) belonging to the Rangareddy district (Telangana, India) along with their micronutrient status, inhibition of acetylcholinesterase activity, and oxidative stress levels. Residues of Chlorpyrifos, Diazinon, Malathion, Monocrotophos and Phosalone were found in the serum samples of FW and FC along with significantly low levels of vitamins and minerals. Inhibition of AChE activity was observed in FW and FC and altered oxidative stress parameters among FW. Correlation studies have found significant associations between the pesticide residues, micronutrients and antioxidant enzymes. The study suggests an association between pesticide exposure coupled with micronutrient deficiency, induced AChE inhibition, and oxidative stress.
营养状况在决定农药毒性可能产生的不良健康后果方面起着重要作用。本研究的目的是评估来自印度特伦甘纳邦兰加雷迪区（Rangareddy district）的农妇（FW）（24-45 岁）和农场儿童（FC）（9-12 岁和 13-15 岁）体内的有机磷农药残留水平及其微量营养素状况、乙酰胆碱酯酶活性抑制和氧化应激水平。在 FW 和 FC 的血清样本中发现了氯吡硫磷、二嗪农、马拉硫磷、久效磷和磷胺的残留，同时维生素和矿物质的含量明显较低。在 FW 和 FC 中观察到 AChE 活性的抑制以及 FW 中氧化应激参数的改变。相关性研究发现，农药残留、微量营养素和抗氧化酶之间存在显著关联。该研究表明，农药暴露与微量营养素缺乏、AChE 抑制和氧化应激之间存在关联。
