Symbiosis Institute of Health Sciences, Symbiosis International (Deemed) University, Pune, India.
Food Safety Division, Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India.
Front Public Health. 2022 Jun 14;10:872125. doi: 10.3389/fpubh.2022.872125. eCollection 2022.
The present interventional study aimed to assess the impact of micronutrient supplementation on pesticide-residues concentrations, vitamins, minerals, acetylcholinesterase activity and oxidative stress among 129 farm children (9-12 years, = 66 and 13-15 years, = 63) involved in farming activities in Ranga Reddy district, Telangana, India. Our data showed the presence of five organophosphorus pesticide residues (chlorpyrifos, diazinon, malathion, monocrotophos, and phosalone) among children before-supplementation (both age-groups); while post-supplementation, only two pesticide residues (chlorpyrifos and diazinon) were detected indicating improved metabolic rate. Vitamin E, copper, magnesium and zinc levels were also improved in both the age-groups and manganese levels were significantly increased only among children of 13-15 years age group. Further, post-supplementation also showed an improvement in acetylcholinesterase activity and a decrease in lipid peroxidation among both the age groups of children. However, further research for ascertaining the ameliorating effect of micronutrients in preventing adverse effects of organophosphorus pesticides must be conducted.
本研究旨在评估补充微量营养素对印度特伦甘纳邦兰加雷迪区从事农业活动的 129 名（9-12 岁，n=66 和 13-15 岁，n=63）农场儿童体内农药残留、维生素、矿物质、乙酰胆碱酯酶活性和氧化应激的影响。我们的数据显示，补充微量营养素前，两组儿童体内均存在五种有机磷农药残留（毒死蜱、二嗪农、马拉硫磷、久效磷和磷胺）；而补充微量营养素后，仅检测到两种农药残留（毒死蜱和二嗪农），表明代谢率有所提高。两组儿童的维生素 E、铜、镁和锌水平也有所提高，而锰水平仅在 13-15 岁年龄组的儿童中显著增加。此外，补充微量营养素后，两组儿童的乙酰胆碱酯酶活性均有所提高，脂质过氧化作用均有所降低。然而，为了确定微量营养素在预防有机磷农药不良影响方面的改善作用，还需要进行进一步的研究。
