National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
PLoS One. 2020 Dec 15;15(12):e0242367. doi: 10.1371/journal.pone.0242367. eCollection 2020.
The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resulting in various congenital malformations in newborns, including microcephaly. This review aimed to describe the o signs and symptoms that characterize the congenital Zika syndrome.
A systematic review was performed with a protocol and described according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The search strategy yielded 2,048 studies. After the exclusion of duplicates and application of inclusion criteria, 46 studies were included. The main signs and symptoms associated with the congenital Zika syndrome were microcephaly, parenchymal or cerebellar calcifications, ventriculomegaly, central nervous system hypoplasia or atrophy, arthrogryposis, ocular findings in the posterior and anterior segments, abnormal visual function and low birthweight for gestational age.
Zika virus infection during pregnancy can cause a series of changes in the growth and development of children, while impacting the healthcare system due to the severity of cases. Our findings outline the disease profile in newborns and infants and may contribute to the development and updating of more specific clinical protocols.
Zika 病毒感染的症状和体征通常较轻且呈自限性。然而，该疾病与神经并发症相关，如格林-巴利综合征和周围神经受累，也与垂直传播导致的流产和胎儿死亡有关，从而导致新生儿出现各种先天性畸形，包括小头畸形。本综述旨在描述先天性 Zika 综合征的特征性体征和症状。
系统综述采用方案进行，并根据系统评价和荟萃分析的首选报告项目的建议进行描述。搜索策略产生了 2048 项研究。在排除重复项并应用纳入标准后，纳入了 46 项研究。与先天性 Zika 综合征相关的主要体征和症状包括小头畸形、实质或小脑钙化、脑室扩大、中枢神经系统发育不良或萎缩、关节挛缩、后段和前段眼部异常、视觉功能异常和小于胎龄儿。
妊娠期间 Zika 病毒感染可导致儿童生长发育出现一系列变化，同时由于病例严重程度而对医疗保健系统造成影响。我们的发现概述了新生儿和婴儿的疾病特征，可能有助于制定和更新更具体的临床方案。
