MFB Division, ICAR- Central Institute of Fisheries Technology, Matsyapuri, Willingdon Island, Cochin 682029, Kerala, India.
ICAR- MRC of CIFT, CIDCO Administrative Building, Sector 1, Vashi, Navi Mumbai 400703, Maharashtra, India.
FEMS Microbiol Lett. 2021 Jan 26;368(1). doi: 10.1093/femsle/fnaa210.
ZnO-Nanoparticle-Chitosan (ZnO-NP-CH) composite has potential biomedical and food applications due to its better antimicrobial activity. However, the presence of nano-metal-oxide in the composite makes the material unsuitable for any food applications. Moreover, the cost involved in the preparation of Zinc Oxide-Nano-Particle (ZnO-NP) is a major limitation for commercial food applications. Hence a suitable alternative for ZnO-NP is highly needed for food application. Since ZnO-Bulk Particles (ZnO-BP) are food grade and there is no study on the composite prepared from ZnO-Bulk Particle-Chitosan (ZnO-BP-CH), in the present study, antimicrobial activity was assessed for ZnO-BP-CH and compared with ZnO-NP-CH. Based on the study, it was observed that in the individual form of ZnO-NP possessed significantly higher antimicrobial activity than ZnO-BP. The composite form of ZnO-NP-CH and ZnO-BP-CH possessed higher antimicrobial activity than chitosan. However, no significant difference was observed between the composite forms. Hence, ZnO-BP-CH could be recommended as a suitable alternative to ZnO-NP-CH for future studies related to chitosan with ZnO composite to avoid costly nanomaterials preparation.
氧化锌-纳米粒子-壳聚糖（ZnO-NP-CH）复合材料具有较好的抗菌活性，在生物医药和食品领域具有潜在的应用。然而，由于纳米金属氧化物的存在，该复合材料不适合应用于任何食品领域。此外，氧化锌纳米粒子（ZnO-NP）的制备成本很高，这是其在商业食品应用中的主要限制因素。因此，需要一种合适的 ZnO-NP 替代品来满足食品应用的需求。由于 ZnO 块状颗粒（ZnO-BP）是食品级的，而且目前尚未研究过由 ZnO 块状颗粒-壳聚糖（ZnO-BP-CH）制备的复合材料，因此在本研究中，评估了 ZnO-BP-CH 的抗菌活性，并与 ZnO-NP-CH 进行了比较。研究结果表明，在单独的 ZnO-NP 形式下，其抗菌活性显著高于 ZnO-BP。ZnO-NP-CH 和 ZnO-BP-CH 的复合形式具有比壳聚糖更高的抗菌活性。然而，复合形式之间没有观察到显著差异。因此，ZnO-BP-CH 可以作为 ZnO-NP-CH 的替代品，用于未来与壳聚糖复合的 ZnO 相关研究，以避免昂贵的纳米材料制备。
