Bio-nanomaterials Research Lab, Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Bio-nanomaterials Research Lab, Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Int J Biol Macromol. 2017 Nov;104(Pt B):1753-1761. doi: 10.1016/j.ijbiomac.2017.02.079. Epub 2017 Mar 6.
A new biopolymer based ZnO-PVP nanocomposite was successfully synthesized by single step in situ precipitation method using chitosan as biosurfactant, zinc chloride as a source material, PVP as stabilizing agent and sodium hydroxide as precipitating agent. The chemical bonding and crystalline behaviors of chitosan, zinc oxide and PVP were confirmed by FT-IR and XRD analysis. The biopolymer connected ZnO particles intercalated PVP matrix was layer and rod like structure appeared in nanometer range confirmed by HR-SEM and TEM analysis. The surface topography image of CS/ZnO-PVP nanocomposite was obtained in the average thickness of 12nm was confirmed by AFM analysis. Thermal stability of cationic biopolymer based ZnO intercalated PVP has higher stability than CS-PVP and chitosan. Consequently, antimicrobial activity of chitosan/ZnO-PVP matrix acts as a better microbial inhibition activity than PVP-ZnO nanocomposite. The obtained above results demonstrate that CS and ZnO intercalated PVP matrix has better reinforced effect than other components. Therefore, Chitosan/ZnO-PVP nanocomposite may be a promising material for the biomedical applications.
采用壳聚糖作为生物表面活性剂，氯化锌为原料，PVP 为稳定剂，氢氧化钠为沉淀剂，通过一步原位沉淀法成功合成了一种新型的基于生物聚合物的 ZnO-PVP 纳米复合材料。FT-IR 和 XRD 分析证实了壳聚糖、氧化锌和 PVP 的化学键合和结晶行为。HR-SEM 和 TEM 分析证实，生物聚合物连接的 ZnO 颗粒插层 PVP 基体呈现层状和棒状结构，尺寸在纳米范围内。AFM 分析证实，CS/ZnO-PVP 纳米复合材料的表面形貌图像的平均厚度为 12nm。阳离子生物聚合物基 ZnO 插层 PVP 的热稳定性比 CS-PVP 和壳聚糖具有更高的稳定性。因此，壳聚糖/ZnO-PVP 基体的抗菌活性表现出比 PVP-ZnO 纳米复合材料更好的微生物抑制活性。所得结果表明，CS 和 ZnO 插层 PVP 基体比其他成分具有更好的增强效果。因此，壳聚糖/ZnO-PVP 纳米复合材料可能是一种有前途的生物医学应用材料。
