2 型糖尿病患者的冠状动脉疾病遗传易感性。
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus.
机构信息
Pat Macpherson Center for Pharmacogenetics & Pharmacogenomics, Cardiovascular & Diabetes Medicine (N.R.v.Z., C.N.A.P.), School of Medicine, University of Dundee.
Oxford Center for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine (N.R.v.Z., N.W.R., N.R.R., A. Mahajan, M.I.Mc), University of Oxford, United Kingdom.
出版信息
Circ Genom Precis Med. 2020 Dec;13(6):e002769. doi: 10.1161/CIRCGEN.119.002769. Epub 2020 Aug 13.
BACKGROUND
Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).
METHODS
To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D).
RESULTS
None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.
CONCLUSIONS
This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.
背景
2 型糖尿病（T2D）患者的冠状动脉疾病（CAD）加速。
方法
为了测试这是否反映了 T2D 患者 CAD 风险的遗传影响的差异，我们在 66643 名受试者（27708 名 CAD 患者和 24259 名 T2D 患者）中对 CAD 和 T2D 之间的遗传重叠进行了系统评估。在进一步的 117787 名受试者（16694 名 CAD 患者和 11537 名 T2D 患者）中评估了在分层分析中显示与 CAD 明显相关或有相互作用证据的变异。
结果
未发现先前确定的 CAD 位点在 T2D 个体中对 CAD 有特定影响，全基因组相互作用分析未发现可被认为是 T2D 特异性的新 CAD 变体。当我们考虑 CAD 与其危险因素之间的总体遗传相关性时，我们发现 T2D 背景对这些关系没有实质性差异。
结论
这项研究没有发现 T2D 患者与非 T2D 患者的 CAD 遗传结构存在差异的证据。
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