Haque Md Ezazul, Azam Shofiul, Balakrishnan Rengasamy, Akther Mahbuba, Kim In-Su
Department of Applied Life Science, Graduate School, Konkuk University, Chungju 27478, Korea.
Department of Biotechnology, College of Biomedical and Health Science, and Research Institute of Inflammatory Disease (RID), Konkuk University, Chungju 27478, Korea.
Plants (Basel). 2020 Dec 13;9(12):1765. doi: 10.3390/plants9121765.
(LO) BLUME from the genus (Lauraceae) is a medicinal herb traditionally used in Southeast Asian countries. Indigenously, extracts of different parts of the plant have been used to improve blood circulation and treat allergy, inflammation, rheumatism, and liver diseases. LO is a rich source of therapeutically beneficial antioxidative phytochemicals, such as flavonoids, butenolides, lignans and neolignans. Moreover, recent studies have unravelled the pharmacological properties of several newly found active constituents of LO, such as anti-inflammatory antioxidants (+)-syringaresinol, linderin A, anti-atherosclerotic antioxidant (+)-episesamin, anti-melanogenic antioxidants quercitrin and afzelin, cytotoxic 2-(1-methoxy-11-dodecenyl)-penta-2,4-dien-4-olide, (2,3,4)-2-(11-dodecenylidene)-3-hydroxy-4-methyl butanolide, anti-allergic koaburaside, (6-hydroxyphenyl)-1-O-beta-d-glucopyranoside and 2,6-dimethoxy-4-hydroxyphenyl-1-O-beta-d-glucopyranoside and the antiplatelet-activity compound Secolincomolide A. These findings demonstrate that LO can be a potential source of antioxidants and other prospective therapeutically active constituents that can lead to the development of oxidative stress-mediated diseases, such as cardiovascular disorders, neurodegenerative disorders, allergies, inflammation, hepatotoxicity, and cancer. Here, the antioxidant properties of different species of genus are discussed briefly. The traditional use, phytochemistry, antioxidative and pharmacological properties of LO are also considered to help researchers screen potential lead compounds and design and develop future therapeutic agents to treat oxidative stress-mediated disorders.
樟科木姜子属的潺槁木姜子是一种传统上在东南亚国家使用的草药。在当地，该植物不同部位的提取物已被用于促进血液循环以及治疗过敏、炎症、风湿和肝脏疾病。潺槁木姜子富含具有治疗益处的抗氧化植物化学物质，如黄酮类化合物、丁烯内酯、木脂素和新木脂素。此外，最近的研究揭示了潺槁木姜子几种新发现的活性成分的药理特性，如抗炎抗氧化剂（+）-丁香树脂醇、乌药醇A、抗动脉粥样硬化抗氧化剂（+）-表芝麻素、抗黑素生成抗氧化剂槲皮苷和阿夫泽林、细胞毒性的2-（1-甲氧基-11-十二碳烯基）-戊-2,4-二烯-4-内酯、（2,3,4）-2-（11-十二碳烯叉）-3-羟基-4-甲基丁醇内酯、抗过敏的考布苷、（6-羟基苯基）-1-O-β-D-吡喃葡萄糖苷和2,6-二甲氧基-4-羟基苯基-1-O-β-D-吡喃葡萄糖苷以及抗血小板活性化合物Secolincomolide A。这些发现表明，潺槁木姜子可能是抗氧化剂和其他潜在治疗活性成分的潜在来源，这些成分可用于开发由氧化应激介导的疾病，如心血管疾病、神经退行性疾病、过敏、炎症、肝毒性和癌症。在此，简要讨论了木姜子属不同物种的抗氧化特性。还考虑了潺槁木姜子的传统用途、植物化学、抗氧化和药理特性，以帮助研究人员筛选潜在的先导化合物，并设计和开发未来治疗氧化应激介导疾病的治疗药物。
