Provisus Eye Clinic, 112 Redzinska str., 42-209 Częstochowa, Poland.
Department of Ophthalmology and Visual Rehabilitation, Central Veterans Hospital, Medical University of Lodz, 113 Zeromskiego str., 90-549 Lodz, Poland.
Int J Environ Res Public Health. 2020 Dec 13;17(24):9331. doi: 10.3390/ijerph17249331.
: In this study, we evaluated the efficacy of topical hypotensive treatment and/or systemic corticosteroids therapy in patients with elevated intraocular pressure and Graves' orbitopathy (GO). : We included 172 eyes in 86 individuals with duration of GO ≥ 3 months, intraocular pressure in either eye ≥ 25.0 mmHg, and GO ranked ≥ 3 at least in one eye in modified CAS form. The study subjects were divided into three treatment subgroups: subgroup I was administered latanoprost once a day; subgroup II was administered a combined preparation of brimonidine and timolol BID; subgroup III was the control group, not receiving any topical hypotensive treatment. All the study participants received systemic treatment, intravenous corticosteroid therapy at the same dose, according to the European Group of Graves' Orbitopathy (EUGOGO) guideline. : On the final visit, the mean IOP value was significantly lower in all treatment subgroups compared to the initial values. In both subgroups receiving topical treatment, the IOP reduction was higher than in the control group receiving systemic corticosteroids only. However, the latanoprost eye drops decreased intraocular pressure more effectively than drops containing brimonidine and timolol. : Topical ocular hypotensive treatment is effective in reducing intraocular pressure in GO and decreases intraocular pressure more effectively than systemic corticosteroid therapy alone.
在这项研究中，我们评估了局部降压治疗和/或全身皮质类固醇治疗对眼压升高和格雷夫斯眼病（GO）患者的疗效。
我们纳入了 86 名患者的 172 只眼，GO 病程≥3 个月，至少一只眼改良 CAS 评分≥3，双眼眼压均≥25.0mmHg。研究对象分为三组治疗亚组：亚组 I 每天点用拉坦前列素一次；亚组 II 每天两次点用溴莫尼定和噻吗洛尔复合制剂；亚组 III 为对照组，未接受任何局部降压治疗。所有研究参与者均按照欧洲格雷夫斯眼病专家组（EUGOGO）指南接受全身治疗，即相同剂量的静脉皮质类固醇治疗。
末次随访时，所有治疗亚组的平均眼压值均较基线值显著降低。在接受局部治疗的两组中，眼压下降幅度高于仅接受全身皮质类固醇治疗的对照组。然而，与含有溴莫尼定和噻吗洛尔的滴眼剂相比，拉坦前列素滴眼液更有效地降低了眼压。
局部眼部降压治疗可有效降低 GO 患者的眼压，且比单独全身皮质类固醇治疗更有效。
