Ophthalmic Plastic Surgery Service, L.V. Prasad Eye Institute, Hyderabad, India.
Int Ophthalmol. 2021 Jan;41(1):231-236. doi: 10.1007/s10792-020-01571-6. Epub 2020 Aug 25.
To assess the demographic and clinical profile of thyroid eye disease (TED) presenting to a Tertiary Eye Care Institute in India.
All patients who were diagnosed to have TED between the year 2007 and 2017 at the Ophthalmic Plastic Surgery Service, LV Prasad Eye Institute, were included in this retrospective observational study. The demographic details of parameters such as age, gender and laterality, presenting signs and symptoms, clinical activity at presentation, and systemic thyroid status were assessed.
A total of 1000 consecutive patients of TED were evaluated in the 10-year period. Average age at presentation was 44.9 years (range 8-89). Of the 1000, 529 (53%) were males, and 358 (36%) had unilateral TED. At presentation, the TED was active (time since onset ≤ 12 months) in 476 (48%) cases and 71 (7%) had dysthyroid optic neuropathy. Of the 913 patients where systemic thyroid status was available at the time of presentation, 342 (37%) were euthyroid at presentation. Of the patients who were active at presentation (n = 476), 349 (70.3%) were 'Silent presenters' (Active as per timeline, but CAS ≤ 3). A prominent eye was the most common presenting symptom in 563 (64%) patients. Presenting signs in order of frequency were proptosis in 582 (58%), lower lid retraction (49%), upper lid retraction (48%), strabismus (6%), ptosis (5.5%), and corneal ulcer (1.3%).
TED in India presents to the tertiary eye center with slight male preponderance. One-third (37%) are euthyroid and half (48%) are active at presentation. One-third (35%) are silent presenters, with minimal clinical activity during the active phase of TED.
评估在印度一家三级眼科保健机构就诊的甲状腺眼病（TED）患者的人口统计学和临床特征。
本回顾性观察研究纳入了 2007 年至 2017 年期间在 LV 普拉萨德眼科研究所眼科整形手术服务部被诊断为 TED 的所有患者。评估了年龄、性别和侧别、就诊时的体征和症状、就诊时的临床活动以及全身甲状腺状态等参数的人口统计学细节。
在 10 年期间，共评估了 1000 例连续 TED 患者。就诊时的平均年龄为 44.9 岁（范围 8-89 岁）。在 1000 例患者中，529 例（53%）为男性，358 例（36%）为单侧 TED。就诊时，476 例（48%）的 TED 处于活动期（发病时间≤12 个月），71 例（7%）患有甲状腺毒性视神经病变。在就诊时可获得全身甲状腺功能状态的 913 例患者中，342 例（37%）就诊时处于甲状腺功能正常状态。在就诊时处于活动期的患者中（n=476），349 例（70.3%）为“无症状患者”（根据时间线为活动期，但 CAS≤3）。突出的眼睛是 563 例（64%）患者最常见的就诊症状。按频率顺序排列的就诊体征是眼球突出 582 例（58%）、下眼睑退缩 49%、上眼睑退缩 48%、斜视 6%、上睑下垂 5.5%和角膜溃疡 1.3%。
印度的 TED 患者就诊于三级眼科中心，男性略占优势。三分之一（37%）为甲状腺功能正常，一半（48%）就诊时处于活动期。三分之一（35%）为无症状患者，在 TED 的活动期，其临床活动最小。
