Sanchez-Morillo Daniel, Lara-Doña Alejandro, Priego-Torres Blanca, Morales-Gonzalez Maria, Montoro-Ballesteros Francisca, Leon-Jimenez Antonio
Biomedical Research and Innovation Institute of Cadiz (INiBICA), Hospital Universitario Puerta del Mar, Avda. Ana de Viya 21, 11009 Cádiz, Spain.
Biomedical Engineering and Telemedicine Research Group, Department of Automation Engineering, Electronics and Computer Architecture and Networks, School of Engineering, University of Cadiz, Avda. Universidad de Cádiz 10, Puerto Real, 11519 Cádiz, Spain.
J Clin Med. 2020 Dec 11;9(12):4007. doi: 10.3390/jcm9124007.
The appropriate titration for the personalized oxygen needs of patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia is a determining factor in the success of long-term oxygen therapy. There are no standardized procedures to assist in determining the patient's needs during the physical activities of daily life. Despite that effort tests are a wide broad approach, further research concerning the development of protocols to titrate O therapy is needed. The main objective of this study was to assess whether the level of oxygen titrated through the 6-minute walking test (6MWT) for patients with COPD and exertional hypoxemia is adequate to meet the patients' demand during their activities of daily living. Physiological and subjective variables were estimated for a study population during two walking tests: a 6MWT and a 20-minute walking circuit (20MWC), designed ad-hoc to reproduce daily physical activities more truthfully. The results indicate that in a significant proportion of patients, the 6MWT might not accurately predict their oxygen needs at a domiciliary environment. Therefore, the titration of the portable O therapy could not be optimal in these cases, with the detrimental impact on the patient's health (hyperoxia episodes), the autonomy of the oxygen device, and the decrease of time out of the home.
对于慢性阻塞性肺疾病（COPD）和严重低氧血症患者的个性化氧需求进行适当滴定是长期氧疗成功的决定性因素。目前尚无标准化程序可协助确定患者在日常生活身体活动期间的需求。尽管运动试验是一种广泛采用的方法，但仍需要进一步研究以制定滴定氧疗的方案。本研究的主要目的是评估通过6分钟步行试验（6MWT）为COPD和运动性低氧血症患者滴定的氧水平是否足以满足其日常生活活动期间的需求。在两项步行试验期间对研究人群的生理和主观变量进行了评估：一项6MWT和一项专门设计用于更真实再现日常身体活动的20分钟步行环路（20MWC）。结果表明，在相当一部分患者中，6MWT可能无法准确预测他们在家居环境中的氧需求。因此，在这些情况下便携式氧疗的滴定可能并非最佳，这会对患者健康（高氧发作）、氧疗设备的自主性以及外出时间减少产生不利影响。
