Bliźniewska-Kowalska Katarzyna, Szewczyk Bernadeta, Gałecka Małgorzata, Su Kuan-Pin, Maes Michael, Szemraj Janusz, Gałecki Piotr
Department of Adult Psychiatry, Medical University of Lodz, 91-229 Lodz, Poland.
Department of Neurobiology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Cracow, Poland.
J Clin Med. 2020 Dec 12;9(12):4018. doi: 10.3390/jcm9124018.
(1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa.
(1) 背景：激活的免疫炎症途径在抑郁症和病理性肥胖的发病机制中起重要作用。肥胖可能促进细胞因子白细胞介素17的产生，其在神经免疫反应中起重要作用。本研究旨在评估体重指数（BMI）与白细胞介素17表达之间的关系，并考虑抑郁症患者的临床精神科变量。(2) 方法：共有125名参与者参加了该研究（95名抑郁症患者，30名健康对照）。收集了有关抑郁症病程和BMI的数据。使用汉密尔顿抑郁量表（HDRS）评估抑郁症状的严重程度。逆转录聚合酶链反应（RT-PCR）用于评估白细胞介素17基因在mRNA水平的表达，而酶联免疫吸附测定（ELISA）用于评估白细胞介素17在蛋白质水平的表达。(3) 结果：住院次数较多的患者白细胞介素17 mRNA表达水平和BMI显著更高。然而，在抑郁症患者中未发现BMI与白细胞介素17表达之间存在相关性。(4) 结论：我们的研究表明，BMI对抑郁症患者的白细胞介素17表达没有影响。然而，应进行进一步研究以评估抑制白细胞介素17对脂肪组织的影响，反之亦然。
