Hallym Data Science Laboratory, College of Medicine, Hallym University, Anyang 14068, Korea.
Department of Otorhinolaryngology-Head & Neck Surgery, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.
Int J Environ Res Public Health. 2020 Dec 12;17(24):9310. doi: 10.3390/ijerph17249310.
Psoriasis is a well-known immune-mediated disease. Its autoimmune pathophysiology is consistent with the immune-mediated systemic vascular hypothesis regarding the pathogenesis of sudden sensorineural hearing loss (SSNHL). The purpose of our study was to investigate whether psoriasis affects the prevalence of SSNHL in all age groups matched by age, sex, income, and region of residence. Korean Health Insurance Review and Assessment Service-National Patient Samples were collected from 2002 to 2013. A 1:4 matched psoriasis group (n = 12,864) and control group (n = 51,456) were selected. The crude (simple) and adjusted (Charlson comorbidity index) hazard ratios (HR) for psoriasis and SSNHL were analyzed using the stratified Cox proportional hazard model. The incidence of SSNHL was significantly higher in the psoriasis group than in the control group (0.5% vs. 0.4%, = 0.004). Psoriasis increased the risk of SSNHL (adjusted HR = 1.44, 95% confidence interval (CI) = 1.09-1.90, = 0.010). In the stratification analysis, the incidence of SSNHL was significantly higher in the 30-59-year-old group than other group SSNHL (adjusted HR = 1.50, 95% CI = 1.06-2.12, = 0.023). In addition, SSNHL occurred significantly more frequently in men with psoriasis (adjusted HR = 1.70, 95% CI = 1.17-2.49, = 0.006). Psoriasis increased the risk of SSNHL, and SSNHL was more prevalent in between the age of 30-59-year-olds and men with psoriasis.
银屑病是一种众所周知的免疫介导性疾病。其自身免疫病理生理学与突发性聋（SSNHL）发病机制的免疫介导性系统性血管假说一致。我们的研究目的是探讨银屑病是否会影响所有年龄组的 SSNHL 患病率，这些年龄组通过年龄、性别、收入和居住地区进行匹配。2002 年至 2013 年，收集了韩国健康保险审查和评估服务-国家患者样本。选择了一组银屑病（n = 12864）和对照组（n = 51456），按 1：4 匹配。使用分层 Cox 比例风险模型分析了银屑病与 SSNHL 的粗（简单）和调整（Charlson 合并症指数）风险比（HR）。银屑病组的 SSNHL 发生率明显高于对照组（0.5%比 0.4%， = 0.004）。银屑病增加了 SSNHL 的发病风险（调整后的 HR = 1.44，95%置信区间（CI）= 1.09-1.90， = 0.010）。在分层分析中，30-59 岁年龄组的 SSNHL 发生率明显高于其他年龄组（调整后的 HR = 1.50，95%CI = 1.06-2.12， = 0.023）。此外，银屑病男性 SSNHL 的发生率明显更高（调整后的 HR = 1.70，95%CI = 1.17-2.49， = 0.006）。银屑病增加了 SSNHL 的发病风险，30-59 岁年龄组和银屑病男性的 SSNHL 更为常见。
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