银屑病与突发性耳聋之间的因果关系：一项孟德尔随机化研究。

Causal relationship between psoriasis and sudden deafness: a Mendelian randomization study.

作者信息

Wu Linrong, Shen Yiming, Zhang Junjun, Shen Zhisen, Li Tian

机构信息

Department of Otolaryngology, Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, 315100, China.

Otology and Skull Base Surgery, National Health Commission Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200000, China.

出版信息

Arch Dermatol Res. 2025 Jan 4;317(1):167. doi: 10.1007/s00403-024-03700-y.

DOI:10.1007/s00403-024-03700-y

PMID:39755810

Abstract

OBJECTIVE

This study aims to investigate the genetic link between psoriasis and sudden sensorineural hearing loss (SSNHL).

METHODS

From a genetic standpoint, this study further highlighted the connection between psoriasis and SSNHL. Single nucleotide polymorphisms (SNPs) connected to SSNHL could be found using a genome-wide association study from the IEU OpenGWAS project website. In addition, the inverse variance weighted (IVW) technique was used to evaluate the connection between psoriasis and SSNHL.

RESULTS

According to Mendelian randomization analysis, IVW supported the causal relationship between psoriasis and SSNHL (OR = 808.86, 95%CI 3.32 ~ 196942.07, P = 0.02). In the sensitivity analysis, there was no heterogeneity or horizontal pleiotropy, and the Leave-one-out analysis suggested that the causal effect was robust.The results of MR-Egger (Q = 13.53, P = 0.76) and IVW (Q = 14.73, P = 0.74) showed that there was no heterogeneity in SNPs, and the results were reliable. We also performed a horizontal pleiotropic analysis (P = 0.29), which showed that there was no horizontal pleiotropy and no confounding factors in the study.

CONCLUSION

From a genetic perspective, there is a causal relationship between psoriasis and an increased risk of sudden sensorineural hearing loss.

摘要

目的

本研究旨在探讨银屑病与突发性感音神经性听力损失（SSNHL）之间的遗传联系。

方法

从遗传学角度来看，本研究进一步突出了银屑病与SSNHL之间的联系。可通过IEU OpenGWAS项目网站的全基因组关联研究找到与SSNHL相关的单核苷酸多态性（SNP）。此外，采用逆方差加权（IVW）技术评估银屑病与SSNHL之间的联系。

结果

根据孟德尔随机化分析，IVW支持银屑病与SSNHL之间的因果关系（OR = 808.86，95%CI 3.32 ~ 196942.07，P = 0.02）。在敏感性分析中，不存在异质性或水平多效性，留一法分析表明因果效应稳健。MR-Egger（Q = 13.53，P = 0.76）和IVW（Q = 14.73，P = 0.74）的结果表明SNP不存在异质性，结果可靠。我们还进行了水平多效性分析（P = 0.29），结果表明研究中不存在水平多效性和混杂因素。