At the Tenth People's Hospital affiliated with Tongji University, Tongji University School of Medicine, in Shanghai, China, Tao Cai, MD, is a resident physician; Lei Zhang, MD, is an attending physician; Kunpeng Zhu, MD, is a physician; Jianping Hu, MD, is a physician; Taichen Zhan, MD, is a physician; Liwei Liu, MD, is an anesthetist; Cheng Li, MD, is an anesthetist; and Chunlin Zhang, MD, is a professor. Acknowledgments: The results of this project were previously reported at the 19th conference of the International Society of Limb Salvage, Osaka, Japan.
Adv Skin Wound Care. 2021 Jan;34(1):1-6. doi: 10.1097/01.ASW.0000723280.71047.73.
To evaluate the clinical outcomes of negative-pressure wound therapy (NPWT) for infection prevention following pelvic reconstruction after malignant bone tumor resection.
The study involved 82 patients who underwent pelvic reconstruction following en-bloc resection of malignant bone tumors between January 2003 and January 2016. Forty patients were treated with NPWT via implantation of vacuum-sealing drainage (VSD) materials into the pelvic cavity to prevent infection and wound problems (VSD group), and the remaining 42 patients underwent conventional treatment (control group). Study authors compared the inpatient length of stay, antibiotic use, drainage volume, time to wound closure, and infection rates between groups. Investigators also conducted cell cultures of the wound cavity washing fluid and hematoxylin-eosin staining for VSD materials to find recurrent tumor cells.
In the VSD group, one patient (2.5%) had a superficial wound problem. In the control group, 18 patients (42.9%) had deep infection or wound problems. The VSD group had a significantly decreased infection rate, duration of antibiotic administration and inpatient stay, as well as increased wound healing compared with the control group (P < .05). Further, no tumor cells were observed in the VSD material or the wound cavity washing fluid.
The application of NPWT with VSD material may be an effective and reliable method for preventing infection in patients who undergo pelvic reconstruction following malignant tumor resection.
评估负压伤口疗法（NPWT）在恶性骨肿瘤切除后骨盆重建中预防感染的临床效果。
本研究纳入了 82 例 2003 年 1 月至 2016 年 1 月间接受整块切除恶性骨肿瘤后骨盆重建的患者。40 例患者采用 NPWT 治疗，即在盆腔内植入真空密封引流（VSD）材料以预防感染和伤口问题（VSD 组），其余 42 例患者采用常规治疗（对照组）。研究人员比较了两组患者的住院时间、抗生素使用、引流量、伤口愈合时间和感染率。研究者还对 VSD 材料的伤口腔冲洗液进行了细胞培养和苏木精-伊红染色，以寻找复发性肿瘤细胞。
VSD 组 1 例（2.5%）患者出现浅表伤口问题，对照组 18 例（42.9%）患者出现深部感染或伤口问题。VSD 组感染率、抗生素使用时间和住院时间明显降低，伤口愈合时间明显延长，与对照组相比差异有统计学意义（P <.05）。此外，VSD 材料和伤口腔冲洗液中均未观察到肿瘤细胞。
NPWT 联合 VSD 材料的应用可能是预防恶性肿瘤切除后骨盆重建患者感染的一种有效且可靠的方法。
