Albónico S M, Assem M E, Benages I A, Montiel A A, Pizzorno M T, Docampo R, Stoppani A O
Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Rev Argent Microbiol. 1987 Jul-Sep;19(3):121-4.
Several new 1,2,3,4-tetrahydrocarbazole, 5,6-dihydrobenzo(alpha) carbazole, 3-methylindole and substituted benzimidazolyl compounds were synthesized and assayed for their action on growth of Trypanosoma cruzi, cultured in Warren's liquid medium. 6-chloro and 6,8-dichloro-N-(1-ethyl-N-diethylamino)-1,2,3,4-tetrahydrocarbazole++ fumarate resulted the more active in inhibiting growth of the parasite. The new compounds were apparently more effective than those prepared previously by Poliakoff et al. (5).
合成了几种新的1,2,3,4-四氢咔唑、5,6-二氢苯并(α)咔唑、3-甲基吲哚和取代苯并咪唑基化合物，并检测了它们对在沃伦液体培养基中培养的克氏锥虫生长的作用。6-氯和6,8-二氯-N-(1-乙基-N-二乙氨基)-1,2,3,4-四氢咔唑富马酸盐在抑制寄生虫生长方面活性更高。这些新化合物显然比波利亚科夫等人(5)之前制备的化合物更有效。
