Icahn School of Medicine at Mount Sinai, New York, NY, USA.
UT Southwestern Medical Centre, Dallas, TX, USA.
Eur Heart J. 2021 Mar 21;42(12):1132-1135. doi: 10.1093/eurheartj/ehaa868.
Hypercholesterolaemia is an important risk factor for cardiovascular disease. Both total and LDL cholesterol levels are three-fold higher at the end of the first year of life and about four-fold higher in adulthood compared with the neonatal period. In the USA, only 25% of infants are exclusively breastfed and simple carbohydrate-rich formulas are preferentially consumed. Spikes in fasting glucose and insulin have been reported in formula-fed infants and are associated with higher levels of proprotein convertase subtilisin/kexin type 9, suggesting a potential link between high simple sugar intake and consequent increase in LDL cholesterol in early childhood.
高胆固醇血症是心血管疾病的一个重要危险因素。与新生儿期相比，在生命的第一年结束时，总胆固醇和 LDL 胆固醇水平高出三倍，而成人则高出四倍。在美国，只有 25%的婴儿是纯母乳喂养，而简单的富含碳水化合物的配方奶则更受青睐。有研究报道，配方奶喂养的婴儿空腹时血糖和胰岛素会出现飙升，并且与前蛋白转化酶枯草溶菌素/克那霉 9 水平升高有关，这表明在儿童早期，高简单糖摄入与 LDL 胆固醇的相应增加之间可能存在联系。
