Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Dermatology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Dermatology. 2021;237(6):891-895. doi: 10.1159/000512190. Epub 2020 Dec 16.
Pain and psychological disorders are the 2 most commonly occurring symptom clusters in patients with postherpetic neuralgia (PHN). This study aimed to investigate the risk factors for anxiety and depressive disorders in patients with PHN.
Retrospectively, we examined the potential risk factors of anxiety and depression among patients with PHN from the clinic medical records of the Third Affiliated Hospital of Sun Yat-Sen University from 2017 to 2019. The Chinese version of the Hospital Anxiety and Depression Scale was used to assess anxiety and depression. Patients were retrospectively allocated to 2 groups - PHN with and without anxiety/depression - and compared to identify the differential patient characteristics.
Cases of 661 patients who were diagnosed with PHN were included. Anxiety and depression developed in 69.0% (456/661) and 65.8% (435/661) of the enrolled patients with PHN, respectively. Results of univariate regression analyses showed that female sex, magnitude of pain intensity, time from onset of rash and extent of spread of rashes were significantly associated with anxiety and depression in patients with PHN. Multivariate analysis revealed that both anxiety and depression states significantly correlated with female sex, magnitude of pain intensity, and extent of spread of rashes.
Anxiety and depression were not uncommon in patients with PHN. Women with PHN who experience severe pain and develop extensive rashes have a high risk of developing anxiety and depressive disorders.
疼痛和心理障碍是带状疱疹后神经痛（PHN）患者最常出现的两种症状群。本研究旨在探讨 PHN 患者焦虑和抑郁障碍的危险因素。
回顾性分析中山大学附属第三医院 2017 年至 2019 年临床病历中 PHN 患者的潜在焦虑和抑郁危险因素。采用汉密尔顿焦虑量表和汉密尔顿抑郁量表评估焦虑和抑郁。将患者回顾性分配到 PHN 伴或不伴焦虑/抑郁两组，并比较两组患者的差异。
共纳入 661 例 PHN 患者。69.0%（456/661）和 65.8%（435/661）的 PHN 患者出现焦虑和抑郁。单因素回归分析结果显示，女性、疼痛强度、皮疹发作时间和皮疹扩散程度与 PHN 患者的焦虑和抑郁显著相关。多因素分析显示，焦虑和抑郁状态与女性、疼痛强度和皮疹扩散程度显著相关。
PHN 患者中焦虑和抑郁并不少见。女性 PHN 患者疼痛剧烈且皮疹扩散范围广，患焦虑和抑郁障碍的风险较高。
