The First Clinical Medical College of Lanzhou University.
Department of Orthopedics, The First Hospital of Lanzhou University, Lanzhou City, Gansu Province, China.
Medicine (Baltimore). 2020 Dec 11;99(50):e23517. doi: 10.1097/MD.0000000000023517.
Symptoms of hand osteoarthritis result in activity limitations and lower quality of life. Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis.
We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis. We will search PubMed, EMBASE, Cochrane Library, and Web of Science using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis.
This study will be submitted to a peer-reviewed journal for publication.
We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials.
INPLASY2020110005.
手部骨关节炎的症状会导致活动受限和生活质量下降。羟氯喹已成功用于治疗许多自身免疫性疾病，它具有抗炎作用，在手骨关节炎中可能也有益处。
我们计划对随机临床试验进行系统评价和荟萃分析，以确定羟氯喹对手部骨关节炎症状的改善作用。我们将使用全面的策略在 PubMed、EMBASE、Cochrane 图书馆和 Web of Science 中进行搜索。还将检查相关会议记录和纳入研究的参考文献列表，以确定其他研究。两位审查员将独立筛选检索记录、提取信息和评估偏倚风险。Stata v15.1 软件将用于进行数据分析。
本研究将提交给同行评议期刊发表。
我们希望它能为临床实践和未来的相关临床试验提供一个相对全面的参考。
INPLASY 注册号：INPLASY2020110005。
