Pilla Rakesh, Palleti Sujith Kumar, Rayana Renuka, Skss Satish Reddy, Abdul Razzack Aminah, Kalla Sruti
Internal Medicine, Maharajah's Institute of Medical Sciences, Vizianagaram, IND.
Internal Medicine, MNR Medical College & Hospital, Sangareddy, IND.
Cureus. 2020 Nov 13;12(11):e11479. doi: 10.7759/cureus.11479.
Diabetes is prevalent in the Indian population, to the extent that the diabetes burden matches that of nutritional anemia. We aimed to determine the effects of iron and vitamin B12 deficiency anemia on glycated haemoglobin (HbA1c) concentrations in individuals without diabetes.
The study comprises 100 patients with iron deficiency anemia, 100 with vitamin B12 deficiency anemia, and 100 healthy volunteers as a control group. Each of the first two groups was subdivided into two groups depending on the severity of anemia based on Hb levels. We treated with iron replenishment in the iron deficiency group and B12 replenishment in the B12 deficiency group for three months. We noted HbA1c levels before and after the therapy. Data were entered into the SPSS package. For comparing pre and post-therapy levels, we used the Paired 't' test.
The mean HbA1c before treatment were 6.1% ± 0.23% and 5.5% ± 0.24%, and the values after treatment were 5.1% ± 0.14% and 4.6% ± 0.2% in severe iron deficiency anemia subgroup and mild to moderate subgroup, respectively. The mean HbA1c in the iron-deficiency anemia control group was 5.2% ± 0.2%. The mean HbA1c levels before treatment were 5.9% ± 0.3% and 5.6% ± 0.19%, and after treatment were 5.0% ± 0.15% and 4.9% ± 0.16% in severe and mild to moderate B12 deficiency anemia, respectively. The mean HbA1c in the vitamin B12 deficiency anemia control group was 5.1% ± 0.2%.
HbA1c in both types of anemia subjects showed a significant decrease with appropriate therapy. Physicians should consider rechecking patient haemoglobin values and correcting a patient's anemia before determining the patient's glycemic status using HbA1c to avoid misinterpretation of their diabetes status.
糖尿病在印度人群中普遍存在，其负担程度与营养性贫血相当。我们旨在确定缺铁和维生素B12缺乏性贫血对非糖尿病个体糖化血红蛋白（HbA1c）浓度的影响。
该研究包括100例缺铁性贫血患者、100例维生素B12缺乏性贫血患者以及100名健康志愿者作为对照组。前两组中的每组根据基于血红蛋白水平的贫血严重程度又分为两组。缺铁组采用铁剂补充治疗，维生素B12缺乏组采用维生素B12补充治疗，为期三个月。我们记录了治疗前后的HbA1c水平。数据录入SPSS软件包。为比较治疗前后的水平，我们使用配对“t”检验。
在严重缺铁性贫血亚组和轻度至中度亚组中，治疗前的平均HbA1c分别为6.1%±0.23%和5.5%±0.24%，治疗后的数值分别为5.1%±0.14%和4.6%±0.2%。缺铁性贫血对照组的平均HbA1c为5.2%±0.2%。在严重和轻度至中度维生素B12缺乏性贫血中，治疗前的平均HbA1c水平分别为5.9%±0.3%和5.6%±0.19%，治疗后分别为5.0%±0.15%和4.9%±0.16%。维生素B12缺乏性贫血对照组的平均HbA1c为5.1%±0.2%。
两种类型贫血患者的HbA1c在适当治疗后均显著下降。医生在使用HbA1c确定患者血糖状态之前，应考虑重新检查患者的血红蛋白值并纠正患者的贫血，以避免对其糖尿病状态的错误解读。
