Gram-Hansen P, Eriksen J, Mourits-Andersen T, Olesen L
Department of Internal Medicine B, Aalborg Hospital, Denmark.
J Intern Med. 1990 Feb;227(2):133-6. doi: 10.1111/j.1365-2796.1990.tb00131.x.
Glycosylated haemoglobin (HbA1c) was measured in 10 patients with iron deficiency anaemia, 10 patients with vitamin B12 deficiency anaemia and 10 healthy controls. Initially there were no significant differences between the groups (P greater than 0.4), but after treatment with iron and vitamin B12 for 3 and 6 weeks, the glycosylated haemoglobin concentration decreased significantly (P less than 0.01). It was concluded that glycosylated haemoglobin is a sensitive marker of the changes in the erythrocyte population that are observed when predominantly immature erythrocytes are being produced.
对10例缺铁性贫血患者、10例维生素B12缺乏性贫血患者和10名健康对照者进行了糖化血红蛋白（HbA1c）检测。最初，各组之间无显著差异（P大于0.4），但在用铁剂和维生素B12治疗3周和6周后，糖化血红蛋白浓度显著下降（P小于0.01）。得出的结论是，糖化血红蛋白是红细胞群体变化的一个敏感标志物，这种变化在主要产生未成熟红细胞时可以观察到。
