Hassanpour Seyed Esmail, Zirakzadeh Hatef, Aghajani Yasaman
Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anesthesiology; Khatam Al Anbia hospital, Tehran, Iran.
World J Plast Surg. 2020 Sep;9(3):309-312. doi: 10.29252/wjps.9.3.309.
Epinephrine is commonly used in plastic and reconstructive surgeries to reduce the blood loss, and to achieveing the lowest and the most effective dosage of epinephrine can improve the results of the surgery.
Thirty two rats were divided in four groups. Local injection of epinephrine solution (3 mL) with concentrations of 1:200,000, 1:400,000 and 1:1,000,000 was undertaken in three different groups; and the fourth group was the control in which 3 mL of normal saline was administered 15 minutes before making the incision. The bleeding amount was compared in these groups.
A significant difference in blood loss was noted between the control and other groups, but no significant difference was present between epinephrine concentrations of 1:200,000, 1:400,000 and 1:1,000,000.
Local injection of epinephrine solution was shown to reduce bleeding from surgical incisions, but the difference between various pinephrine concentrations was not significant. The use of the lowest concentration (1:1,000,000) was suggested to decrease epinephrine side effects.
肾上腺素常用于整形和重建手术中以减少失血，并且达到最低且最有效的肾上腺素剂量可改善手术效果。
32只大鼠被分为四组。在三个不同组中局部注射浓度为1:200,000、1:400,000和1:1,000,000的肾上腺素溶液（3毫升）；第四组为对照组，在切口前15分钟给予3毫升生理盐水。比较这些组的出血量。
对照组与其他组之间的失血量存在显著差异，但1:200,000、1:400,000和1:1,000,000的肾上腺素浓度之间无显著差异。
局部注射肾上腺素溶液可减少手术切口出血，但不同肾上腺素浓度之间的差异不显著。建议使用最低浓度（1:1,000,000）以减少肾上腺素的副作用。
