Sourg Hanadi Abdelgadir Ahmed, Ahmed Adil Ballal Mohammed, Elhakeem Ramaze Farouke, Lutfi Mohamed Faisal
Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Faculty of Medicine, Al Neelain University, Khartoum, Sudan.
J Clin Transl Res. 2020 Jul 13;6(1):27-35. eCollection 2020 Jul 16.
Pathophysiology of hypertension and bronchial asthma (BA) shares many similarities, especially those related to the metabolic syndrome (MS).
In this study, the indicators of the MS were evaluated in normoglycemic normotensive asthmatic patients to clarify if the components of the MS can still interact to increase the risk of BA, provided that blood pressure and glucose level are kept within the normal physiological ranges.
Body mass index (BMI), waist circumference (WC), mean arterial blood pressure (MABP), fasting blood glucose (FBG) and fasting blood insulin (FBI) levels, the quantitative insulin sensitivity check index (QUICKI), serum lipid profile, and spirometric measurements were all compared between 120 asthmatic patients and 59 non-asthmatic subjects. Cigarette smoking, pregnancy, age below 20 years or above 40 years, diabetes mellitus and hypertension, and other chronic diseases were excluded from all studied groups.
Asthmatic patients demonstrated higher WC (median [25-75 interquartile]=88.50 [78.00-101.75], FBI [19.98 (11.12-40.14)], and triglyceride (TG) level [109.5 (76.50-134.0)]) compared with non-asthmatic subjects (81.00 [72.00-92.00], 13.78 [8.84-30.24], and 89.00 [64.25-104], <0.05). QUICKI and MABP were lower in asthmatic patients (0.310 [0.283-0.338] and 86.66 [83.33-93.33]) compared with non-asthmatic subjects (0.320 [0.297-0.353] and 93.33 [83.33-93.33]), (<0.05). BMI, FBG, low-density lipoprotein, high-density lipoprotein, and total cholesterol levels were comparable in the studied groups.
The present finding gives further evidence for higher WC, FBI, TG level, and insulin resistance in normotensive, normoglycemic asthmatic patients compared to healthy controls.
The findings of this study suggested that abdominal obesity, hypertriglyceridemia, hyperinsulinemia, and insulin resistance may still be interacting and hence increase the risk of BA in normotensive, normoglycemic subjects.
高血压与支气管哮喘（BA）的病理生理学有许多相似之处，尤其是与代谢综合征（MS）相关的方面。
在本研究中，对血糖正常、血压正常的哮喘患者的MS指标进行评估，以明确在血压和血糖水平保持在正常生理范围内的情况下，MS的各组分是否仍会相互作用增加患BA的风险。
比较了120例哮喘患者和59例非哮喘受试者的体重指数（BMI）、腰围（WC）、平均动脉压（MABP）、空腹血糖（FBG）和空腹血胰岛素（FBI）水平、定量胰岛素敏感性检查指数（QUICKI）、血脂谱以及肺功能测量值。所有研究组均排除吸烟、妊娠、20岁以下或40岁以上、糖尿病、高血压及其他慢性疾病。
与非哮喘受试者相比，哮喘患者的WC（中位数[四分位间距25 - 75]=88.50[78.00 - 101.75]）、FBI[19.98（11.12 - 40.14）]和甘油三酯（TG）水平[109.5（76.50 - 134.0）]更高（P<0.05）。哮喘患者的QUICKI和MABP低于非哮喘受试者（分别为0.310[0.283 - 0.338]和86.66[83.33 - 93.33]，与0.320[0.297 - 0.353]和93.33[83.33 - 93.33]相比），（P<0.05）。研究组之间的BMI、FBG、低密度脂蛋白、高密度脂蛋白和总胆固醇水平相当。
目前的研究结果进一步证明，与健康对照组相比，血压正常、血糖正常的哮喘患者的WC、FBI、TG水平及胰岛素抵抗更高。
本研究结果表明，腹型肥胖、高甘油三酯血症、高胰岛素血症及胰岛素抵抗可能仍会相互作用，从而增加血压正常、血糖正常的受试者患BA的风险。
