Hu Yanyan, Chen Jinbo, Yang Lu, Chen Pin, Li Juhong, Chen Lin, Chen Jin, Huang Xiangqin, Zhang Yaping, Bu Shizhong, Huang Qin
Department of Endocrinology, Changhai Hospital, Shanghai 200433, PR China.
Tenth People's Hospital, Tongji University, Shanghai 200072, PR China.
J Clin Transl Endocrinol. 2014 Jul 23;1(4):133-139. doi: 10.1016/j.jcte.2014.07.001. eCollection 2014 Dec.
To analyze the correlation between neck circumference (NC) and non-alcoholic fatty liver disease (NAFLD) and compare the predictive value of NC for NAFLD with that of other simple anthropometric measures and other biochemical profiles.
2761 subjects, undergoing a medical check-up at the Changhai Hospital between October 01, 2012 and November 30, 2012, were recruited to the study. NC, other simple anthropometric measures, and biochemical profiles were analyzed.
NC in NAFLD subjects with or without elevated ALT were 38.94 ± 2.62 cm and 37.21 ± 3.06 cm respectively, which was significantly higher than that in subjects with other metabolic disorders (NC: 35.33 ± 3.03 cm) and in normal controls (NC: 32.60 ± 2.37) (both < 0.001). NC in women with NAFLD increased by 1 cm and fasting insulin (FINS) and homeostasis model assessment-insulin resistance (HOMA-IR) increased by 1.87 mIU/L and 1.43, respectively. Compared with other anthropometric measures, neck circumference-height ratio (NHtR) had a significant impact both on the incidence of NAFLD. After adjustment for sex, abdominal obesity and other influencing factors, the incidence of NAFLD still tended to positively correlate with NC. Optimal cut-off points of NC and NHtR for predicting NAFLD in males were 37.25 cm and 0.224, respectively, and such points in females were 32.90 cm and 0.208, respectively.
NC was wider in NAFLD patients than in healthy subjects and other metabolic disorder sufferers. NC and NHtR could be used as simple predictive tools for NAFLD.
分析颈围（NC）与非酒精性脂肪性肝病（NAFLD）之间的相关性，并比较NC对NAFLD的预测价值与其他简单人体测量指标及其他生化指标的预测价值。
选取2012年10月1日至2012年11月30日在长海医院进行体检的2761名受试者纳入研究。分析其颈围、其他简单人体测量指标及生化指标。
谷丙转氨酶（ALT）升高和未升高的NAFLD受试者的颈围分别为38.94±2.62 cm和37.21±3.06 cm，显著高于其他代谢紊乱受试者（颈围：35.33±3.03 cm）和正常对照组（颈围：32.60±2.37 cm）（均P<0.001）。患有NAFLD的女性颈围每增加1 cm，空腹胰岛素（FINS）和稳态模型评估胰岛素抵抗（HOMA-IR）分别增加1.87 mIU/L和1.43。与其他人体测量指标相比，颈围身高比（NHtR）对NAFLD的发病率均有显著影响。在调整性别、腹型肥胖及其他影响因素后，NAFLD的发病率仍与颈围呈正相关。预测男性NAFLD的颈围和NHtR的最佳切点分别为37.25 cm和0.224，女性分别为32.90 cm和0.208。
NAFLD患者的颈围比健康受试者和其他代谢紊乱患者更宽。颈围和颈围身高比可作为NAFLD的简单预测工具。
