Ikeda Nobutaka, Hiroi Yukio
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
Department of Cardiology, National Center for Global Health and Medicine, Tokyo, Japan.
Glob Health Med. 2019 Dec 31;1(2):83-87. doi: 10.35772/ghm.2019.01031.
The serum 1,5-anhydro-d-glucitol (1,5-AG) level rapidly decreases concomitantly with urinary glucose excretion in hyperglycemia. 1,5-AG is a sensitive clinical marker of short-term glycemic control, postprandial hyperglycemia and glucose fluctuation. Increasing evidence about the relationship between cardiovascular disease (CVD) and glucose fluctuations have been published. In this review, we summarize the possibilities and limitations of 1,5-AG as a marker of CVD. Research showed that 1,5-AG level is associated with prevalence of CVD and is also a predictive value for cardiovascular (CV) events. Especially in a high risk population, the predictive value of 1,5-AG for CV events becomes more effective. Besides, 1,5-AG is an effective glycometabolic marker that complements HbA1c in terms of glucose fluctuation. Appropriate use of 1,5-AG might lead to improved prognosis for patients or decrease medical financial burden of the population through early detection of glucose disorder and quality glucose control.
在高血糖状态下，血清1,5-脱水-d-葡萄糖醇（1,5-AG）水平会随着尿糖排泄而迅速下降。1,5-AG是短期血糖控制、餐后高血糖和血糖波动的敏感临床指标。关于心血管疾病（CVD）与血糖波动之间关系的证据越来越多。在本综述中，我们总结了1,5-AG作为CVD标志物的可能性和局限性。研究表明，1,5-AG水平与CVD患病率相关，对心血管（CV）事件也具有预测价值。尤其是在高危人群中，1,5-AG对CV事件的预测价值更为有效。此外，1,5-AG是一种有效的糖代谢标志物，在血糖波动方面可补充糖化血红蛋白（HbA1c）。合理使用1,5-AG可能通过早期发现血糖紊乱和实现优质血糖控制，改善患者预后或减轻人群的医疗经济负担。
