Tsuzuki Shinya, Matsunaga Nobuaki, Ohmagari Norio
AMR Clinical Reference Center, National Center for Global Health and Medicine, Tokyo, Japan.
Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Glob Health Med. 2020 Jun 30;2(3):164-167. doi: 10.35772/ghm.2020.01005.
Antimicrobial resistance (AMR) is currently a global health threat. Many countries have issued their own national action plans following the publication of the Global Action Plan on AMR by the World Health Organization. The government of Japan established its own National Action Plan on AMR in 2016; however, Japan's AMR countermeasures are still in the developmental stage. Recently, the AMR Clinical Reference Center (AMR CRC) in Japan estimated the disease burden of AMR in the form of number of deaths attributed to blood-stream infections caused by antimicrobial-resistant organisms. However, a more extensive and precise assessment is needed to understand the disease burden of AMR more clearly and enable us to compare these indicators with those published by other countries. Cassini and colleagues from the World Health Organization estimated the disease burden of AMR in the European Union as disability-adjusted life years (DALYs) in 2018. Their study could be considered an important milestone in terms of its thoroughness. If we hope to estimate the disease burden of AMR in a more precise manner, age-stratified patient data is needed in conjunction with a surveillance report. At present, AMR CRC is attempting to establish such data for examination at the national level - a challenging but worthwhile task.
抗菌药物耐药性（AMR）目前是一项全球健康威胁。在世界卫生组织发布《抗菌药物耐药性全球行动计划》之后，许多国家都出台了各自的国家行动计划。日本政府于2016年制定了本国的《抗菌药物耐药性国家行动计划》；然而，日本对抗菌药物耐药性的应对措施仍处于发展阶段。最近，日本的抗菌药物耐药性临床参考中心（AMR CRC）以抗菌药物耐药菌引起的血流感染导致的死亡人数形式估算了抗菌药物耐药性的疾病负担。然而，需要进行更广泛、精确的评估，以便更清楚地了解抗菌药物耐药性的疾病负担，并使我们能够将这些指标与其他国家公布的指标进行比较。世界卫生组织的卡西尼及其同事在2018年将欧盟抗菌药物耐药性的疾病负担估算为伤残调整生命年（DALYs）。就其全面性而言，他们的研究可被视为一个重要的里程碑。如果我们希望以更精确的方式估算抗菌药物耐药性的疾病负担，就需要结合监测报告的年龄分层患者数据。目前，AMR CRC正在尝试建立此类数据以便在国家层面进行审查——这是一项具有挑战性但值得去做的任务。
