Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Cochin, Kerala, India.
Nat Prod Res. 2022 Mar;36(5):1306-1310. doi: 10.1080/14786419.2020.1860041. Epub 2020 Dec 17.
Chitosan is more prominent in food applications due to its versatile properties. Anthocyanins have gained much research attention due to their multifaceted role in preventing various lifestyle ailments. Encapsulated anthocyanin- loaded chitosan nanoparticles (ACNPs) were prepared by conventional ionotropic gelation method. In the present study, the gastro-protective effect of encapsulated ACNPs was evaluated against absolute ethanol-hydrochloric acid (HCl-Ethanol mixture) induced gastric ulcer in male Wistar rats. The histopathology and microscopic scoring of ulcer data of stomach tissue sections revealed that oral administration of encapsulated ACNPs group can alleviate inflammation of induced-gastric ulcer. Further, the expression of anti-inflammatory cytokines (Interleukin 4, IL-4) and suppression of pro-inflammatory cytokines (Interferon gamma, IFN-γ) confirm the cytoprotective effect of encapsulated ACNPs against HCl-Ethanol induced necrotic damage to mucosal membrane. The results of the present study indicate that the gastro protective action of encapsulated ACNPs ascribable to at least in parts to its anti-inflammatory property.[Formula: see text].
壳聚糖由于其多功能特性，在食品应用中更为突出。花色苷由于其在预防各种生活方式疾病方面的多方面作用，引起了广泛的研究关注。通过传统的离子凝胶化方法制备了负载花色苷的壳聚糖纳米颗粒（ACNPs）。在本研究中，评估了包封的 ACNPs 对雄性 Wistar 大鼠的乙醇-盐酸（HCl-乙醇混合物）诱导的胃溃疡的胃保护作用。胃组织切片的组织病理学和溃疡数据的显微镜评分表明，包封的 ACNPs 组的口服给药可以减轻诱导性胃溃疡的炎症。此外，抗炎细胞因子（白细胞介素 4，IL-4）的表达和促炎细胞因子（干扰素 γ，IFN-γ）的抑制证实了包封的 ACNPs 对 HCl-乙醇诱导的粘膜膜坏死损伤的细胞保护作用。本研究的结果表明，包封的 ACNPs 的胃保护作用至少部分归因于其抗炎特性。[公式：见正文]。
