Gaziantep University School of Medicine, Department of Cardiology. 27100, Gaziantep, Turkey.
Adana City Training & Research Hospital, Department of Cardiology, Adana, Turkey.
Rev Assoc Med Bras (1992). 2020 Dec;66(12):1707-1711. doi: 10.1590/1806-9282.66.12.1707.
The aim of this study was to investigate the association between intraocular pressure (IOP) and premature atherosclerotic coronary artery disease (PACAD) by comparing central corneal thicknesses (CCTs) measurements.
One hundred-eighty-six subjects were enrolled in this cross-sectional study, 100 in the PACAD group and 86 in the control group. All participants underwent a physical examination and routine biochemical tests. Ophthalmological examinations, including IOP and CCTs measurements, were performed for each subject. Additionally, pulse wave velocity measurements were obtained and recorded.
Participants with PACAD showed significantly higher IOP values than those without atherosclerosis (p = 0.001), and there was no statistically significant difference between the groups in terms of CCT (p = 0.343). Also, pulse wave velocity (PWV) values were statistically significantly higher in the PACAD group (p = 0.001). High IOP was not significantly associated with metabolic syndrome parameters (p > 0.05).
A relationship was found between PACAD and IOP, but CCTs were not associated with PACAD. The IOP measurement is affected by CCT; therefore, CCT is used to correct IOP values. To our knowledge, this is the first study to report a positive relationship between PACAD and IOP based on CCTs measurements.
本研究旨在通过比较中央角膜厚度（CCT）测量值，探讨眼内压（IOP）与早发动脉粥样硬化性冠心病（PACAD）之间的关联。
本横断面研究纳入了 186 名受试者，其中 100 名在 PACAD 组，86 名在对照组。所有参与者均接受了体格检查和常规生化检查。对每位受试者进行眼科检查，包括 IOP 和 CCT 测量值，并记录脉搏波速度（PWV）测量值。
PACAD 患者的 IOP 值明显高于无动脉粥样硬化患者（p = 0.001），两组 CCT 值无统计学差异（p = 0.343）。此外，PACAD 组的 PWV 值明显更高（p = 0.001）。高 IOP 与代谢综合征参数无显著相关性（p > 0.05）。
本研究发现 PACAD 与 IOP 之间存在关联，但 CCT 与 PACAD 无关。IOP 测量值受 CCT 影响，因此，使用 CCT 校正 IOP 值。据我们所知，这是第一项基于 CCT 测量值报告 PACAD 与 IOP 之间存在正相关关系的研究。
