Department of Microbiology, Combined Military Hospital, Chottogram, Bangladesh.
Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
J Med Virol. 2021 Aug;93(8):5177-5181. doi: 10.1002/jmv.26739. Epub 2020 Dec 29.
Hepatitis E virus (HEV) infection is a significant public health issue in many developing countries, causing waterborne outbreaks as well as sporadic hepatitis. We report here an outbreak of HEV genotype 1f infection during April-May 2018 among people living at Halisohor, a low land in the southern part of Chottogram District of Bangladesh. A total of 933 patients were admitted to Combined Military Hospital (CMH), Chottogram, with symptoms of acute hepatitis. Among them, 550 patients were tested by ELISA for HEV-specific (IgM) and all were positive. Genotyping, sequencing, and phylogenetic analysis based on ORF2 region revealed that the outbreak was caused by genotype 1f and the strains were closely related to the previously reported HEV strains that caused the outbreak in Bangladesh in 2010. The current outbreak was most likely linked with water supply as fecal contamination in water was evident and could be prevented by ensuring access to safe drinking water.
戊型肝炎病毒（HEV）感染是许多发展中国家的一个重大公共卫生问题，可引起水源性暴发和散发性肝炎。我们在此报告 2018 年 4 月至 5 月期间在孟加拉国南部乔塔巴德区哈利绍霍尔生活的人群中发生的 1 型 f 基因型 HEV 感染暴发。共有 933 名患者因急性肝炎入住乔塔巴德综合军事医院（CMH）。其中，550 名患者通过 ELISA 检测 HEV 特异性（IgM），结果均为阳性。基于 ORF2 区的基因分型、测序和系统进化分析显示，暴发是由 1 型 f 引起的，这些毒株与 2010 年在孟加拉国引起暴发的先前报告的 HEV 株密切相关。目前的暴发很可能与供水有关，因为水中粪便污染明显，确保获得安全饮用水可预防这种情况。
