van Crevel Reinout, van der Meer Jos W M, Netea Mihai G
Radboud UMC, afd. Interne Geneeskunde, Nijmegen.
Contact: Reinout van Crevel (
Ned Tijdschr Geneeskd. 2020 Oct 7;164:D5552.
A number of clinical trials are currently underway worldwide to assess whether BCG, the old vaccine against tuberculosis, can protect against COVID-19 infection. In this Perspective, we briefly outline the background, the immunological mechanisms (in particular induction of 'innate immune memory' or 'trained immunity'), and further considerations for the potential future use of BCG against viral and other infections.
目前全球正在进行多项临床试验，以评估抗结核病老疫苗卡介苗（BCG）是否能预防新型冠状病毒肺炎（COVID-19）感染。在这篇观点文章中，我们简要概述了其背景、免疫机制（特别是“固有免疫记忆”或“训练免疫”的诱导），以及未来卡介苗在预防病毒感染和其他感染方面潜在应用的进一步考量。
