Boes J, Dofferhoff A S M, Fleuren H W H A, Kramers C
Radboudumc, afd. Longziekten, Nijmegen.
Canisius-Wilhelmina Ziekenhuis, afd. Interne Geneeskunde, Nijmegen.
Ned Tijdschr Geneeskd. 2020 Nov 19;164:D4868.
Fluoroquinolones are frequently prescribed antibiotics. Recently, the Dutch medicines evaluation board CBG warned about the risk of aortic aneurysms and dissections with the use of fluoroquinolones. We reviewed the three articles used in this warning. We consider that the evidence for a causal relationship is limited. The hazard ratio for the association with fluoroquinolones and aortic aneurysms was around 2. The absolute risk is low given the low prevalence in the general population. However, aortic aneurysms and dissections are life-threatening conditions and must be taken serious. We advise what to do in case of known aortic aneurysms or the presence of multiple risk factors.
氟喹诺酮类药物是常用的抗生素。最近，荷兰药品评估委员会（CBG）就使用氟喹诺酮类药物引发主动脉瘤和主动脉夹层的风险发出了警告。我们查阅了此次警告所依据的三篇文章。我们认为，因果关系的证据有限。氟喹诺酮类药物与主动脉瘤关联的风险比约为2。鉴于一般人群中发病率较低，绝对风险也较低。然而，主动脉瘤和主动脉夹层是危及生命的疾病，必须予以重视。我们就已知主动脉瘤或存在多种风险因素的情况给出了应对建议。
