Mancheva Mimi, Paljoskovska Jordanova Savetka, Bosevski Marijan
Vascular Laboratory, University Clinic of Cardiology, University "Ss. Cyril and Methodius", Skopje, R.N. Macedonia.
Vascular Laboratory, University Clinic of Cardiology, University "Ss. Cyril and Methodius", Skopje, R.N. Macedonia; Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, R.N. Macedonia.
Angiol Sosud Khir. 2020;26(4):11-16. doi: 10.33529/ANGIO2020412.
Carotid intima-media thickness (CIMT) is a double line pattern measured from the lumen-intima to media-adventitia interface. Measuring CIMT with B-mode ultrasound can detect early arterial wall changes. We aimed to measure CIMT in manifested atherosclerotic disease and find a relation to present risk factors.
This cross sectional study included a population of 657 patients, with documented coronary artery disease (CAD), 66,1% were men (469 pts), 33,9% were women (241 pts). The mean age of patients was 64,72 years (55,6-73,8). The measurement of CIMT (maximal and mean) was performed with B-mode ultrasound, on longitudinal view, on multiple plaque-free segments at the level of common carotid artery, on the far wall, on both sides. Multivariate regression analysis was done to estimate independent factors for CIMT, when risk factors, age, and sex included in analysis.
The mean value of maximal CIMT was 0,96 mm (0,52-1,4), mean value of mean CIMT was 0,88 mm (range 0,61-1,15) and mean systolic blood pressure of 133,21 mm Hg (108,03-158,39) was found. Increased CIMT was found in 75,7% of patients (502 pts). Smoking was found as an independent risk factor for increased CIMT with odds ratio (OR) 4,7 (95% CI; 0,67-5,32) and diabetes mellitus with OR 1,6 (95% CI; 0,47-2,16).
Diabetes and smoking are independently related to increased CIMT. These are preliminary results of National survey on 657 pts with coronary artery disease.
颈动脉内膜中层厚度（CIMT）是从管腔内膜至中膜-外膜界面测量的双线模式。用B型超声测量CIMT可检测早期动脉壁变化。我们旨在测量已确诊动脉粥样硬化疾病患者的CIMT，并找出其与当前危险因素的关系。
这项横断面研究纳入了657例有冠状动脉疾病（CAD）记录的患者，其中66.1%为男性（469例），33.9%为女性（241例）。患者的平均年龄为64.72岁（55.6 - 73.8岁）。使用B型超声在纵向视图下，于双侧颈总动脉远壁的多个无斑块节段测量CIMT（最大值和平均值）。在分析中纳入危险因素、年龄和性别后，进行多变量回归分析以评估CIMT的独立影响因素。
最大CIMT的平均值为0.96毫米（0.52 - 1.4），平均CIMT的平均值为0.88毫米（范围0.61 - 1.15），平均收缩压为133.21毫米汞柱（108.03 - 158.39）。75.7%的患者（502例）CIMT升高。发现吸烟是CIMT升高的独立危险因素，比值比（OR）为4.7（95%置信区间；0.67 - 5.32），糖尿病的OR为1.6（95%置信区间；0.47 - 2.16）。
糖尿病和吸烟与CIMT升高独立相关。这些是对657例冠状动脉疾病患者进行全国性调查的初步结果。
