Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China.
Org Biomol Chem. 2021 Jan 21;19(2):365-369. doi: 10.1039/d0ob02037k.
A CuH-catalyzed Z-selective partial reduction of alkynyl amides to afford α,β-unsaturated amides using silane as the hydrogen donor is developed. This reaction is carried out under mild conditions and able to accommodate a broad scope of alkynyl amides including those bearing a terminal carbon-carbon double bond or triple bond, affording alkenyl amides with high stereoselectivity and excellent yields.
发展了一种 CuH 催化的 Z-选择性炔基酰胺部分还原反应，使用硅烷作为氢供体，得到α,β-不饱和酰胺。该反应在温和条件下进行，能够适应广泛的炔基酰胺底物，包括末端碳-碳双键或三键的炔基酰胺，高立体选择性和优异收率地得到烯基酰胺。
