Department of Obstetrics and Gynecology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Department of Gynecology, Women and Children's Hospital of Guangdong, Guangzhou, Guangdong, China.
Int J Gynaecol Obstet. 2021 Aug;154(2):195-203. doi: 10.1002/ijgo.13541. Epub 2021 Jun 8.
To compare 1- and 2-day drug administration interval between mifepristone and misoprostol for second-trimester pregnancy termination and provide evidence-based recommendations.
Search strategy: the search was performed in Pubmed, EMBASE, and Cochrane Library for the relevant published studies from their establishment to March 2020.
randomized controlled trials (RCTs) comparing 1- and 2-day time interval of mifepristone-misoprostol for termination of pregnancy during second-trimester pregnancy were considered. Data were processed using Revman 5.3 software.
Meta-analyses of three RCTs showed no significant difference was reported in the induction-to-abortion time and successful abortion rate between 1- and 2-day mifepristone and misoprostol intervals. Statistical difference was not identified in the induction-to-abortion time between the two drug administration intervals in nulliparous or parous women.
Both 1- and 2-day dosing intervals between mifepristone and misoprostol are suitable for clinical use for second-trimester medical termination of pregnancy.
比较米非司酮和米索前列醇用于中期妊娠终止的 1 天和 2 天给药间隔，并提供基于证据的推荐意见。
检索策略：从建库至 2020 年 3 月，在 Pubmed、EMBASE 和 Cochrane Library 中对相关已发表的研究进行了检索。
纳入比较米非司酮-米索前列醇用于中期妊娠终止时 1 天和 2 天给药间隔的随机对照试验（RCT）。使用 Revman 5.3 软件处理数据。
3 项 RCT 的荟萃分析显示，米非司酮和米索前列醇 1 天和 2 天给药间隔的诱导至流产时间和流产成功率无显著差异。在初产妇或经产妇中，两种药物给药间隔的诱导至流产时间无统计学差异。
米非司酮和米索前列醇的 1 天和 2 天给药间隔均适用于临床用于中期妊娠药物终止。
