Department of Dermatology, University of California, Irvine, Irvine, CA, USA.
Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Int J Dermatol. 2021 Oct;60(10):e383-e389. doi: 10.1111/ijd.15362. Epub 2020 Dec 17.
Neuropathic ulcers or diabetic foot ulcers are preventable ulcers associated with diabetes mellitus. These ulcers occur in the setting of unrecognized trauma, peripheral neuropathy, and foot deformities; however, they are often complicated by peripheral arterial disease and infection. Approximately 15% of individuals with a neuropathic ulcer require limb amputation as a result of infection. Not only are neuropathic ulcers a burden to the patient but also to the economy. The cost of diabetic foot ulcer care is approximately $1.38 billion per year. This makes neuropathic ulcers an important therapeutic target. This review presents the pathophysiology, clinical presentation, evaluation, management, and prevention of neuropathic ulcers.
神经病变性溃疡或糖尿病足溃疡是与糖尿病相关的可预防溃疡。这些溃疡发生在未被识别的创伤、周围神经病变和足部畸形的情况下；然而，它们通常因外周动脉疾病和感染而变得复杂。大约 15%的神经病变性溃疡患者因感染需要截肢。神经病变性溃疡不仅给患者带来负担，也给经济带来负担。糖尿病足溃疡护理的成本约为每年 13.8 亿美元。这使得神经病变性溃疡成为一个重要的治疗目标。本文综述了神经病变性溃疡的病理生理学、临床表现、评估、治疗和预防。
