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糖尿病足溃疡:当代评估与管理。

Diabetic Foot Ulcers: Contemporary Assessment And Management.

机构信息

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

出版信息

J Pak Med Assoc. 2023 Jul;73(7):1480-1487. doi: 10.47391/JPMA.6634.

Abstract

Diabetic foot ulcer disease is the combination of vasculopathy, neuropathy and infection. It is important to identify the main aetiology and to treat it for optimal ulcer healing so that limb amputation may be prevented. A literature review spanning five years (2018-2021) was performed to assess the current understanding of these aetiologies and management options for their treatment. Peripheral artery disease is prevalent in patients with diabetes. Before performing any amputations, whether minor or major, vascular supply in these patients needs to be evaluated and, if needed, improved. Diabetic neuropathy is a long-term complication of uncontrolled diabetes. Patients' education is very important with respect to selfcare and prevention of foot complications arising out of minor trauma in diabetic population. Better foot care and regular use of off-loading shoe wear can prevent neuropathic diabetic foot ulcers. Infection in diabetic patients is mostly polymicrobial and it can present as superficial or deep infections. Early diagnosis, use of broad-spectrum antibiotics, and aggressive debridement, when needed, is advocated to prevent foot amputation. Contemporary treatment armamentarium provides many options for treating diabetic foot ulcers. Nevertheless, one must exhaust all preventive strategies to avoid ulcers in the first place. Once an ulcer has developed, it should be managed aggressively with appropriate soft tissue and, if required, with bony procedures. The current narrative review was planned to explore the current understanding about the main aetiologies of diabetic foot ulcers and about the available treatment options.

摘要

糖尿病足溃疡病是血管病变、神经病变和感染的综合病症。重要的是要确定主要病因,并进行治疗以实现最佳溃疡愈合,从而预防肢体截肢。进行了一项为期五年(2018-2021 年)的文献回顾,以评估目前对这些病因的理解以及治疗这些病因的治疗选择。患有糖尿病的患者中普遍存在外周动脉疾病。在进行任何截肢手术之前,无论是小手术还是大手术,都需要评估这些患者的血管供应情况,并在必要时进行改善。糖尿病神经病变是未控制的糖尿病的长期并发症。患者的教育非常重要,包括自我护理和预防糖尿病患者因轻微创伤而导致的足部并发症。更好的足部护理和定期使用减压鞋可以预防神经性糖尿病足溃疡。糖尿病患者的感染大多为多微生物感染,可表现为浅表或深部感染。早期诊断、使用广谱抗生素和必要时积极清创,以预防足部截肢。当代治疗手段为治疗糖尿病足溃疡提供了许多选择。然而,首先必须用尽所有预防策略来避免溃疡的发生。一旦发生溃疡,应通过适当的软组织处理,如果需要,还应进行骨处理,积极进行治疗。本综述旨在探讨目前对糖尿病足溃疡主要病因的理解以及现有的治疗选择。

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