Department of Allergology, Hôpital d'Enfants Armand Trousseau, APHP, Paris, France.
Sorbonne Universités, Equipe EPAR, Institut Pierre Louis d'Epidémiologie et de Santé Publique, INSERM, Paris, France.
Pediatr Allergy Immunol. 2021 May;32(4):702-708. doi: 10.1111/pai.13435. Epub 2021 Jan 12.
Over the last few decades, the level of pollen from birch and homologous trees has increased in parts of Europe. Sensitization to birch pollen allergens (principally Bet v 1) has been associated with food cross-reactivity called pollen food allergy syndrome (PFAS).
To evaluate changes in allergic diseases due to IgE sensitization over 25 years in asthmatic children.
This was a cross-sectional retrospective study conducted in Paris. We analyzed two cohorts of asthmatic children with similar characteristics explored between 1993-1999 (old cohort = OC) and 2012-2018 (recent cohort = RC).
121 children were in the OC and 120 in the RC. An increase in sensitization to tree pollens was found especially for birch pollen, which was 11.6% in the OC and 31% in the RC (P = .0002). Allergic rhinitis prevalence was significantly higher in the RC than in the OC (96% vs 52%, respectively, P < .0001). IgE-mediated food allergy increased from 6% to 16% in the OC and RC, respectively, (P = .01) mainly due to PFAS. In the RC, a higher mean Bet v 1-specific IgE level was observed in children with PFAS compared to children without (105.7 KU/L ± 17.8 and 48.9 kU/L ± 15.7, respectively, P < .05).
Allergic rhinitis and food allergy with tree pollen sensitization have increased in Paris over 25 years mainly due to PFAS. Environmental factors could be responsible for these modifications as described in the literature.
在过去的几十年中，桦树和同源树种的花粉水平在欧洲部分地区有所上升。桦树花粉过敏原（主要是 Bet v 1）致敏与食物交叉反应有关，称为花粉食物过敏综合征（PFAS）。
评估 25 年来因 IgE 致敏而导致的过敏性疾病在哮喘儿童中的变化。
这是一项在巴黎进行的横断面回顾性研究。我们分析了两组具有相似特征的哮喘儿童，分别在 1993-1999 年（旧队列=OC）和 2012-2018 年（新队列=RC）进行了研究。
OC 中有 121 名儿童，RC 中有 120 名儿童。发现对树木花粉的致敏性增加，特别是桦树花粉，在 OC 中为 11.6%，在 RC 中为 31%（P=0.0002）。RC 中过敏性鼻炎的患病率明显高于 OC（分别为 96%和 52%，P<0.0001）。OC 和 RC 中 IgE 介导的食物过敏分别从 6%增加到 16%（P=0.01），主要是由于 PFAS。在 RC 中，与没有 PFAS 的儿童相比，患有 PFAS 的儿童的 Bet v 1 特异性 IgE 水平更高（分别为 105.7 KU/L±17.8 和 48.9 kU/L±15.7，P<0.05）。
在过去的 25 年中，由于主要是由于 PFAS，巴黎的过敏性鼻炎和食物过敏与树木花粉致敏性增加。正如文献中所述，环境因素可能是这些变化的原因。
