European Commission, Joint Research Centre (JRC), Geel, Belgium.
European Commission, Joint Research Centre (JRC), Geel, Belgium.
Food Chem. 2021 May 30;345:128739. doi: 10.1016/j.foodchem.2020.128739. Epub 2020 Dec 8.
A HPLC-UV/FLD method was validated for the quantification of six polyethylene terephthalate (PET) and four polybutylene terephthalate (PBT) oligomers. PBT oligomers are EU regulated, while the PET ones are considered non-intentionally added substances (NIAS). LOQs were higher than 0.4 and 3.5 μg kg for the simulants and in the polymer extracts, respectively. Recoveries ranged from 95 to 114 % with RSDs below 12%. Migration testing of PBT and polypropylene coffee capsules were performed with HO and simulant C, and extracts were obtained with accelerated solvent extraction (ASE). For the latter legislative limits weren't surpassed. As no migration limits are existing for the analytes, both EFSA's toxicological threshold of concern (TTC) and sum of oligomers approaches were applied. The majority of oligomers were below the TTC (90 µg/person/day), but the limit value of 50 µg/kg food was surpassed for some capsules, which indicates a significant intake in both single and multiple consumption.
建立了高效液相色谱-紫外/荧光检测法（HPLC-UV/FLD），用于定量分析六种聚对苯二甲酸乙二醇酯（PET）和四种聚对苯二甲酸丁二醇酯（PBT）低聚物。PBT 低聚物受欧盟法规监管，而 PET 低聚物被认为是非故意添加物质（NIAS）。模拟物和聚合物提取物中的定量限（LOQ）分别高于 0.4 和 3.5μg/kg。回收率在 95%至 114%之间，相对标准偏差（RSD）低于 12%。用 HO 和模拟物 C 对 PBT 和聚丙烯咖啡胶囊进行了迁移测试，并采用加速溶剂萃取（ASE）提取了提取物。对于后者，并未超过法规限制。由于针对分析物不存在迁移限量，因此应用了 EFSA 的毒理学关注阈值（TTC）和低聚物总量方法。大多数低聚物低于 TTC（90μg/人/天），但对于一些胶囊，食品中 50μg/kg 的限量值被超过，这表明在单次和多次摄入时摄入量都很大。
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