Liu Yingxue, Liu Kai, Zheng Ping, Yin Shanshan, Jin Hangbiao, Bai Xiaoxia, Li Yongqing, Zheng Jingxian, Dai Yishuang, Zhao Meirong, Liu Weiping
Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institution of Environmental Health, Zhejiang University, Hangzhou, 310058, China.
Division of Engineering and Applied Science, W. M. Keck Laboratories, California Institute of Technology, 1200 East California Blvd., Pasadena, CA, 91125, USA.
Environ Pollut. 2021 Feb 1;270:116202. doi: 10.1016/j.envpol.2020.116202. Epub 2020 Dec 6.
Data on gestational exposure characteristics and transplacental transfer are quite limited for perfluoroalkyl substance (PFAS) isomers, especially those from large-scale comparative studies. To fill this gap, we examined isomers of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) in matched maternal and cord serum from Mianyang and Hangzhou, which are located in the upper and lower reaches of the Yangtze River, China, respectively. These data were compared with those from our previous study on Wuhan in the middle reach. The average ΣPFAS concentration increased from upstream to downstream (Mianyang (4.44 ng/mL) < Wuhan (9.88 ng/mL) < Hangzhou (19.72 ng/mL)) and may be related to the per capita consumption expenditure of each city. The ln-transformed PFAS concentrations showed significant differences between Mianyang and Hangzhou after adjusting confounding factors (p < 0.05). The percentages of linear PFOS and PFOA in maternal and cord serum from these cities all exceeded those in electrochemical fluorination products. The isomer profiles of PFASs in maternal and cord serum might be greatly influenced by local production processes of PFASs and residents' dietary habits. The transplacental transfer efficiencies decreased significantly with increasing concentrations in maternal serum for ΣPFAS, ΣPFOS, ΣPFOA, ΣPFHxS, n-PFOS, iso-PFOS, 4m-PFOS, 1m-PFOS, n-PFOA, n-PFHxS, and br-PFHxS (Spearman rank correlation coefficients (r) = 0.373-0.687, p < 0.01). These findings support an understanding of the regional characteristics in maternal exposure to PFASs along the Yangtze River, isomeric profiles of PFASs in these regions, and the transplacental transfer processes of PFAS isomers.
关于全氟烷基物质（PFAS）异构体的孕期暴露特征和经胎盘转移的数据非常有限，尤其是来自大规模比较研究的数据。为了填补这一空白，我们检测了来自中国长江上游的绵阳和下游的杭州的配对母血和脐血血清中的全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）和全氟己烷磺酸（PFHxS）异构体。这些数据与我们之前对中游武汉的研究数据进行了比较。全氟烷基物质（ΣPFAS）的平均浓度从上游到下游升高（绵阳（4.44纳克/毫升）＜武汉（9.88纳克/毫升）＜杭州（19.72纳克/毫升）），可能与每个城市的人均消费支出有关。在调整混杂因素后，ln转换后的全氟烷基物质浓度在绵阳和杭州之间存在显著差异（p＜0.05）。这些城市母血和脐血血清中线性PFOS和PFOA的百分比均超过了电化氟化产品中的百分比。母血和脐血血清中全氟烷基物质的异构体谱可能受到全氟烷基物质当地生产工艺和居民饮食习惯的极大影响。对于ΣPFAS、ΣPFOS、ΣPFOA、ΣPFHxS、n-PFOS、iso-PFOS、4m-PFOS、1m-PFOS、n-PFOA、n-PFHxS和br-PFHxS，经胎盘转移效率随着母血血清中浓度的增加而显著降低（斯皮尔曼等级相关系数（r） = 0.373 - 0.687，p＜0.01）。这些发现有助于了解长江沿线孕妇接触全氟烷基物质的区域特征、这些区域全氟烷基物质的异构体谱以及全氟烷基物质异构体的经胎盘转移过程。
