Cheeloo College of Medicine, Shandong University, 250014 Jinan, China.
Neurobiology Institute, Jining Medical University, 272067 Jining, China.
Neuropeptides. 2021 Feb;85:102112. doi: 10.1016/j.npep.2020.102112. Epub 2020 Dec 11.
Ghrelin is a regulatory peptide that is the endogenous ligand of the growth hormone secretagogue 1a (GHS-R1a) which belongs to the G protein-coupled receptor family. Ghrelin and GHS-R1a are widely expressed in the central and peripheral tissues and play therapeutic potential roles in the cytoprotection of many internal organs. Endoplasmic reticulum stress (ERS), oxidative stress, and autophagy dysfunction, which are involved in various diseases. In recent years, accumulating evidence has suggested that ghrelin exerts protective effects by regulating ERS, oxidative stress, and autophagy in diverse diseases. This review article summarizes information about the roles of the ghrelin system on ERS, oxidative stress, and autophagy in multiple diseases. It is suggested that ghrelin positively affects the treatment of diseases and may be considered as a therapeutic drug in many illnesses.
胃饥饿素是一种调节肽，是生长激素促分泌素 1a（GHS-R1a）的内源性配体，属于 G 蛋白偶联受体家族。胃饥饿素和 GHS-R1a 广泛表达于中枢和外周组织，在许多内脏器官的细胞保护中发挥治疗潜力作用。内质网应激（ERS）、氧化应激和自噬功能障碍与多种疾病有关。近年来，越来越多的证据表明，胃饥饿素通过调节 ERS、氧化应激和自噬在多种疾病中发挥保护作用。本文综述了胃饥饿素系统在多种疾病中对 ERS、氧化应激和自噬的作用的相关信息。提示胃饥饿素对疾病的治疗有积极影响，在许多疾病中可能被视为一种治疗药物。
