同源框转录因子En1是腺样囊性癌和多形性腺癌可能的诊断标志物。
Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma.
作者信息
Baba Shunichi, Akashi Takumi, Kayamori Kou, Ohuchi Tomoyuki, Ogawa Ikuko, Kubota Nobuhisa, Nakano Keisuke, Nagatsuka Hitoshi, Hasegawa Hiromasa, Matsuzaka Kenichi, Tomii Shohei, Uchida Keisuke, Katsuta Noriko, Sekiya Takahiro, Ando Noboru, Miura Keiko, Ishibashi Hironori, Ariizumi Yousuke, Asakage Takahiro, Michi Yasuyuki, Harada Hiroyuki, Sakamoto Kei, Eishi Yoshinobu, Okubo Kenichi, Ikeda Tohru
机构信息
Department of Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Thoracic Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
出版信息
Pathol Int. 2021 Feb;71(2):113-123. doi: 10.1111/pin.13050. Epub 2020 Dec 17.
Diagnostic utility of a homeobox transcription factor, engrailed homeobox 1 (En1) in the histopathology of salivary gland neoplasms was studied. The expression of En1 was immunohistochemically examined in 51 cases of adenoid cystic carcinoma (AdCC) and 143 cases of other salivary gland neoplasms. In all 51 AdCCs, En1 was expressed in 30-100% of tumor cells. In eight of nine polymorphous adenocarcinomas (PACs), En1 was expressed in 40-100% of tumor cells. Less than 5% of tumor cells expressed En1 in three of 12 epithelial-myoepithelial carcinomas, one of 17 basal cell adenomas (BCAs), and one of 34 pleomorphic adenomas (PAs). Among 55 other carcinoma cases, 1-30% of tumor cells expressed En1 in three salivary duct carcinomas (SDCs) ex PA. None of the myoepitheliomas and Warthin tumors expressed En1. When the cut-off value of the percentage of En1-expressing cells was set to 25%, all 51 AdCCs, eight of nine PACs and one SDC ex PA were En1-positive and the others were En1-negative. En1 is expressed consistently in AdCCs, frequently in PACs, but rarely in other salivary gland neoplasms. En1 is a possible diagnostic marker for AdCC and PAC in the histopathology of salivary gland neoplasms.
研究了一种同源框转录因子—— engrailed 同源框 1（En1）在涎腺肿瘤组织病理学中的诊断效用。采用免疫组织化学方法检测了 51 例腺样囊性癌（AdCC）和 143 例其他涎腺肿瘤中 En1 的表达情况。在所有 51 例 AdCC 中，30% - 100%的肿瘤细胞表达 En1。在 9 例多形性腺癌（PAC）中的 8 例中，40% - 100%的肿瘤细胞表达 En1。在 12 例上皮 - 肌上皮癌中的 3 例、17 例基底细胞腺瘤（BCA）中的 1 例以及 34 例多形性腺瘤（PA）中的 1 例中，不到 5%的肿瘤细胞表达 En1。在 55 例其他癌病例中，3 例涎腺导管癌（SDC）（源自 PA）中有 1% - 30%的肿瘤细胞表达 En1。所有肌上皮瘤和沃辛瘤均未表达 En1。当将 En1 表达细胞百分比的截断值设定为 25%时，所有 51 例 AdCC、9 例 PAC 中的 8 例以及 1 例源自 PA 的 SDC 为 En1 阳性，其他为 En1 阴性。En1 在 AdCC 中持续表达，在 PAC 中频繁表达，但在其他涎腺肿瘤中很少表达。En1 可能是涎腺肿瘤组织病理学中 AdCC 和 PAC 的诊断标志物。
Zotero 插件