Shu W, Zhao R L, Duan J W, Li M L, Li L, Zhao F F, Li Z A, Amaerjiang Nubiya, Xiao H D, Hu Y F
Department of Child and Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing 100069, China.
Department of School Health, Shunyi District Center for Disease Control and Prevention, Beijing 101300, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Dec 6;54(12):1383-1388. doi: 10.3760/cma.j.cn112150-20200612-00874.
To explore the association between blood pressure (BP) and the left ventricular mass (LVM) in children aged 6-8 years. The participants were from the community-based census-like design child cohort on sensitization, puberty, obesity and cardiovascular risk (PROC) conducted in six public non-boarding primary schools in Shunyi District, Beijing. Repeated three measurements on anthropometrical, M-mode and 2-dimensional (2D) echocardiographic imaging (2D/M ECHO) and blood biochemical assay, and BP measurements were carried out at baseline and follow-up from October 2018 to June 2019. A total of 1 659 children who had repeated BP measurements and cardiac structure information were included in this study. The average value of last two measurements of BP was determined as BP value for analysis. Formula recommended by Devereux was used to calculate the mass of left ventricle. Robust linear regression models were used to explore the association between BP and LVM in different groups. The average age of all patients was (7.10±0.29) years old, including 832 boys (50.15%). Of all, 83.54% (1 386/1 659) were grouped as normal BP with average LVM (58.54±13.33) g, and 16.46% (273/1 659) as elevated BP group with LVM (63.84±15.78) g (<0.001). The LVM of the normal BP group was lower than elevated BP group in overall participants, boys and girls (<0.005). Univariate analysis showed that systolic BP was associated with LVM in overall, boys and girls (<0.001) respectively. While diastolic BP was associated with LVM in overall and girls (<0.03). Multivariable analysis indicated that the associations between systolic BP and LVM were observed in overall, boys and girls (<0.05) with the β (95%)=0.14 (0.08, 0.21), 0.18 (0.08, 0.27) and 0.12 (0.03, 0.22), respectively. However, the associations of diastolic BP and LVM were not significant. Systolic BP is highly associated with LVM and elevated BP could increase the LVM in children. Boys with elevated BP present a larger LVM and might indicate higher risk of left ventricular hypertrophy in adulthood.
探索6至8岁儿童血压（BP）与左心室质量（LVM）之间的关联。参与者来自于在北京顺义区六所公立非寄宿制小学开展的基于社区普查样设计的儿童队列研究，该研究涉及致敏、青春期、肥胖与心血管风险（PROC）。在2018年10月至2019年6月的基线期和随访期，对人体测量学指标、M型和二维（2D）超声心动图成像（2D/M ECHO）以及血液生化指标进行了三次重复测量，并测量了血压。本研究纳入了1659名有重复血压测量值和心脏结构信息的儿童。将血压最后两次测量的平均值确定为用于分析的血压值。采用Devereux推荐的公式计算左心室质量。使用稳健线性回归模型探索不同组中血压与左心室质量之间的关联。所有患者的平均年龄为（7.10±0.29）岁，其中男孩832名（50.15%）。其中，83.54%（1386/1659）被归为血压正常组，平均左心室质量为（58.54±13.33）g，16.46%（2
