Dai W Y, Zhang Y Q, Zhang Q, Yang R, Zhao M, Xi B
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University/Children Cardiovascular Research Center of Shandong University, Ji'nan 250012, China.
Department of Food Nutrition and Child Health Care, Zibo Center for Disease Control and Prevention, Zibo 255026, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Dec 6;54(12):1402-1407. doi: 10.3760/cma.j.cn112150-20200610-00853.
To examine the association of abdominal obesity assessed by waist circumference (WC) with carotid intima-media thickness (cIMT) in children. The study participants were from the "Huantai Childhood Cardiovascular Health Cohort Study" conducted in Huantai County, Zibo City, Shandong Province. A convenient cluster sampling method was used to select a primary school in Huantai County to conduct the baseline survey from November 2017 to January 2018. A total of 1 515 children aged 6-11 years old were included. The first follow-up survey was conducted from November to December 2019, and a total of 981 children aged 8-13 years old were finally included after exclusion of those with high cIMT at baseline. Questionnaire survey, physical examination and ultrasonic examination were used to collect general demographic characteristics, WC and cIMT information. According to the status of WC at baseline, the participants were divided into normal WC group and abdominal obesity group. Covariance analysis was used to compare the cIMT levels of children between normal WC group and abdominal obesity group. Multivariable logistic regression models were used to evaluate the association between baseline abdominal obesity and high cIMT during the follow-up. The age of 981 children was (8.5±1.5) years at the baseline. The follow-up age was (10.5±1.5) years, and 520 boys accounted for 53.0%. The cIMT of children in the abdominal obesity group was 0.54 mm, which was higher than that in the normal WC group (0.51 mm) (0.001). Similarly, the prevalence of high cIMT in children with abdominal obesity (23.9%) was higher than that of normal WC group (3.9%) (<0.001). After adjusting for potential covariates at the baseline and during the follow-up period, compared with the normal WC group, abdominal obesity was significantly associated with high cIMT (5.78, 95%:3.43-9.74). The abdominal obesity in children could increase the risk of high cIMT.
研究儿童中通过腰围（WC）评估的腹型肥胖与颈动脉内膜中层厚度（cIMT）之间的关联。研究参与者来自于在山东省淄博市桓台县开展的“桓台儿童心血管健康队列研究”。采用便利整群抽样方法在桓台县选择一所小学，于2017年11月至2018年1月进行基线调查。共纳入1515名6至11岁儿童。首次随访调查于2019年11月至12月进行，排除基线时cIMT高的儿童后，最终共纳入981名8至13岁儿童。采用问卷调查、体格检查和超声检查收集一般人口统计学特征、WC和cIMT信息。根据基线时WC状况，将参与者分为正常WC组和腹型肥胖组。采用协方差分析比较正常WC组和腹型肥胖组儿童的cIMT水平。使用多变量逻辑回归模型评估基线腹型肥胖与随访期间高cIMT之间的关联。981名儿童基线时年龄为（8.5±1.5）岁。随访时年龄为（10.5±1.5）岁，520名男孩占53.0%。腹型肥胖组儿童的cIMT为0.54mm，高于正常WC组（0.51mm）（P<0.001）。同样，腹型肥胖儿童中高cIMT的患病率（23.9%）高于正常WC组（3.9%）（P<0.001）。在对基线和随访期间的潜在协变量进行调整后，与正常WC组相比，腹型肥胖与高cIMT显著相关（比值比5.78，95%可信区间：3.43 - 9.74）。儿童腹型肥胖会增加高cIMT的风险。
