Cinar Mehmet Ulas, Mousel Michelle R, Herndon Maria K, Taylor J Bret, White Stephen N
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA.
Department of Animal Science, Faculty of Agriculture, Erciyes University, Kayseri 38039, Turkey.
Animals (Basel). 2020 Dec 15;10(12):2391. doi: 10.3390/ani10122391.
Signature of selection studies have identified many genomic regions with known functional importance and some without verified functional roles. Multiple studies have identified Transmembrane protein 8B ( as having been recently under extreme selection pressure in domesticated sheep, but no study has provided sheep phenotypic data clarifying a reason for extreme selection. We tested for production trait association in 770 U.S. Rambouillet, Targhee, Polypay, and Suffolk sheep. was associated with mature weight at 3 and 4 years ( < 0.05). This suggested selection for sheep growth and body size might explain the historical extreme selection pressure in this genomic region. We also tested Sperm-associated antigen 8 () encoding a G493C substitution. While this variant was associated with mature weights at ages 3 and 4, it was not as strongly associated as Transmembrane protein 8B has little functional information except as an inhibitor of cancer cell proliferation. To our knowledge, this is the first study linking to whole organism growth and body size under standard conditions. Additional work will be necessary to identify the underlying functional variant(s). Once identified, such variants could be used to improve sheep production through selective breeding.
选择研究的特征已识别出许多具有已知功能重要性的基因组区域，以及一些尚未证实功能作用的区域。多项研究已确定跨膜蛋白8B（Transmembrane protein 8B）最近在驯化绵羊中处于极端选择压力之下，但尚无研究提供绵羊表型数据来阐明极端选择的原因。我们对770只美国兰布耶羊、塔吉羊、波利佩羊和萨福克羊的生产性状关联进行了测试。跨膜蛋白8B与3岁和4岁时的成熟体重相关（P<0.05）。这表明对绵羊生长和体型的选择可能解释了该基因组区域历史上的极端选择压力。我们还测试了编码G493C替代的精子相关抗原8（Sperm-associated antigen 8）。虽然该变体与3岁和4岁时的成熟体重相关，但其相关性不如跨膜蛋白8B。除了作为癌细胞增殖的抑制剂外，跨膜蛋白8B几乎没有功能信息。据我们所知，这是第一项在标准条件下将跨膜蛋白8B与整个生物体生长和体型联系起来的研究。有必要开展更多工作来识别潜在的功能变体。一旦识别出来，这些变体可用于通过选择性育种来提高绵羊产量。
