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基于环糊精的功能性糖纳米材料

Cyclodextrin-Based Functional Glyconanomaterials.

作者信息

Rivero-Barbarroja Gonzalo, Benito Juan Manuel, Ortiz Mellet Carmen, García Fernández José Manuel

机构信息

Department of Organic Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain.

Instituto de Investigaciones Químicas (IIQ), CSIC, Universidad de Sevilla, 41092 Sevilla, Spain.

出版信息

Nanomaterials (Basel). 2020 Dec 15;10(12):2517. doi: 10.3390/nano10122517.

DOI:10.3390/nano10122517
PMID:33333914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7765426/
Abstract

Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as "off-the-shelve" tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for their selective functionalization, in combination with "click" multiconjugation procedures, have further leveraged the nanoscaffold nature of these oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly contributed to understand and exploit the interactions between multivalent glycodisplays and carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties of nanomaterials through host-guest strategies. The whole range of capabilities can be enabled through self-assembly, template-assisted assembly or covalent connection of CD/glycan building blocks. This review discusses the advancements made in this field during the last decade and the amazing variety of functional glyconanomaterials empowered by the versatility of the CD component.

摘要

由于环糊精（CDs）具有生物相容性和包合能力的独特组合，长期以来在大多数制药实验室中作为“现成可用”的工具，在操纵多种活性成分的药代动力学方面占据着突出地位。用于其选择性功能化的精密化学方法的发展，与“点击”多共轭程序相结合，进一步利用了这些寡糖的纳米支架性质，在糖世界和纳米世界之间建立了直接联系。CDs极大地有助于理解和利用多价糖展示与碳水化合物结合蛋白（凝集素）之间的相互作用，并通过主客体策略改善纳米材料的载药和功能特性。通过CD/聚糖构建块的自组装、模板辅助组装或共价连接，可以实现所有这些功能。本综述讨论了过去十年该领域取得的进展，以及由CD组分的多功能性赋予的各种令人惊叹的功能性糖纳米材料。

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