Department of Gynecology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours, France.
Laboratoire N2C « Nutrition, Croissance et Cancer », Université de Tours, INSERM UMR1069, 10 Boulevard Tonnellé, 37032 Tours, France.
Nutrients. 2020 Dec 15;12(12):3832. doi: 10.3390/nu12123832.
In the present study, we investigated various biochemical, clinical, and histological factors associated with bone metastases in a large cohort of pre- and postmenopausal women with breast cancer. Two hundred and sixty-one consecutive women with breast cancer were included in this study. Breast adipose tissue specimens were collected during surgery. After having established the fatty acid profile of breast adipose tissue by gas chromatography, we determined whether there were differences associated with the occurrence of bone metastases in these patients. Regarding the clinical and histological criteria, a majority of the patients with bone metastases (around 70%) had tumors with a luminal phenotype and 59% of them showed axillary lymph node involvement. Moreover, we found a negative association between the levels of 3 long-chain polyunsaturated fatty acids (LC-PUFA) in breast adipose tissue and the development of bone metastases in premenopausal women. No significant association was observed in postmenopausal women. In addition to a luminal phenotype and axillary lymph node involvement, low levels of 3 LC-PUFA in breast adipose tissue may constitute a risk factor that contributes to breast cancer bone metastases formation in premenopausal women.
在本研究中，我们调查了 261 例连续的乳腺癌绝经前和绝经后女性患者的各种生化、临床和组织学因素与骨转移的相关性。本研究纳入了 261 例连续的乳腺癌患者。在手术过程中收集了乳腺脂肪组织标本。通过气相色谱法确定了乳腺脂肪组织的脂肪酸谱后，我们确定了这些患者中是否存在与骨转移发生相关的差异。在临床和组织学标准方面，大多数骨转移患者（约 70%）的肿瘤具有腔型表型，其中 59%的患者腋窝淋巴结受累。此外，我们发现绝经前妇女乳腺脂肪组织中 3 种长链多不饱和脂肪酸（LC-PUFA）水平与骨转移的发生呈负相关。在绝经后妇女中未观察到显著相关性。除了腔型表型和腋窝淋巴结受累外，乳腺脂肪组织中 3 种 LC-PUFA 水平较低可能是绝经前妇女乳腺癌骨转移形成的一个危险因素。
