Finco D R, Rawlings C A, Crowell W A, Brown S A, Barsanti J A
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens.
J Vet Intern Med. 1987 Apr-Jun;1(2):61-6. doi: 10.1111/j.1939-1676.1987.tb01988.x.
Sixteen mongrel dogs had bilateral nephrectomy and received a renal allograft from an unmatched mongrel. One group of eight dogs was treated orally with azathioprine and prednisone; another group of eight dogs was treated orally with cyclosporine and prednisone. Four dogs of each group received four blood transfusions each prior to surgery. Mean survival time was nearly the same in the azathioprine-treated and the cyclosporine-treated dogs. Transfusions prolonged survival in the azathioprine-treated group but not in the cyclosporine-treated group. Retrospective measurement of whole blood trough cyclosporine concentrations indicated marked variation between dogs and in the same dog at different times. This variation may have influenced graft survival. Only one dog survived the 9-month period of observation, indicating that refinements of the techniques used in this study will be required for long-term survival of renal allografts in unrelated mongrel dogs.
16只杂种犬接受双侧肾切除，并接受来自不匹配杂种犬的同种异体肾移植。一组8只犬口服硫唑嘌呤和泼尼松；另一组8只犬口服环孢素和泼尼松。每组4只犬在手术前各接受4次输血。硫唑嘌呤治疗组和环孢素治疗组的平均存活时间几乎相同。输血延长了硫唑嘌呤治疗组的存活时间，但对环孢素治疗组没有作用。对全血中环孢素谷浓度的回顾性测量表明，不同犬之间以及同一犬在不同时间存在显著差异。这种差异可能影响了移植物的存活。只有1只犬存活至9个月的观察期，这表明要使不相关杂种犬的同种异体肾移植长期存活，需要改进本研究中使用的技术。
